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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MAGOH

mago-nashi homolog, proliferation-associated (Drosophila)

Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.

Gene Name: mago-nashi homolog, proliferation-associated (Drosophila)
Synonyms: MAGOH, MAGOHA, MAGOH1, Mago nashi protein homolog, Protein mago nashi homolog
Target Sequences: NM_002370 NP_002361.1 P61326


MAGOH Antibody - MAGOH Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human stomach tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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Rabbit Polyclonal to Human MAGOH
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
MAGOH Antibody - Immunohistochemistry of paraffin-embedded human kidney tissue at dilution of 1:100
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Rabbit Polyclonal (IgG) to Human MAGOH
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µl   $235.00; 100µl   $285.00
MAGOH Antibody - 1:100 staining human breast carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human MAGOH
Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
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Rabbit Polyclonal (IgG) to Human MAGOH
Human
ELISA, IHC, IP, WB
Unconjugated
100µg   $375.00
Select
Rabbit Polyclonal (IgG) to Human MAGOH
Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
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Rabbit Polyclonal (IgG) to Human MAGOH
Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human MAGOH
Human
ELISA, IHC, WB
FITC Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human MAGOH
Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human MAGOH
Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human MAGOH
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human MAGOH
Human
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
MAGOH Antibody - Western blot All Lanes: MAGOH antibody at 4.36 ug/ml Lane 1: Mouse kidney tissue Lane 2: A431 whole cell lysate Lane 3: Jurkat whole cell lysate Lane 4: Raji whole cell lysate Lane 5: K562 whole cell lysate Lane 6: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 18,13 kDa Observed band size: 17 kDa
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Rabbit Polyclonal (IgG) to Human MAGOH
Human
ELISA, IP, WB
Unconjugated
50µl   $235.00; 100µl   $285.00
MAGOH Antibody - MAGOH monoclonal antibody (M01), clone 6E11. Western blot of MAGOH expression in HeLa.
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Mouse Monoclonal [clone 6E11] (IgG1,k) to Human MAGOH
Human
ELISA, WB
Unconjugated
100µg   $365.00
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Rabbit Polyclonal to Human MAGOH
Human
ELISA, IP, WB
Unconjugated
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
MAGOH Antibody - MAGOH antibody (1 ug/ml) staining of nuclear HeLa lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Goat Polyclonal to Human MAGOH
Xenopus, Chicken, Zebrafish, Insect, Drosophila, Pig, Horse, Bat, Bovine, Rabbit, Mouse, Dog, Rat, Hamster, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100µg   0.5mg/ml   $405.00
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Mouse Monoclonal (IgG1) to Human MAGOH
Human
WB
Unconjugated, Azide-free
100µg   $560.00
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Rabbit Polyclonal (IgG) to Human MAGOH
Mouse, Rat, Human
WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
MAGOH Antibody - MAGOH antibody Western blot of MCF7 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human MAGOH
Xenopus, Chicken, Zebrafish, Drosophila, Pig, Horse, Bat, Rat, Hamster, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
MAGOH Antibody - MAGOH antibody Western blot of MCF7 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human MAGOH
Xenopus, Chicken, Zebrafish, Drosophila, Rat, Hamster, Bat, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee
WB
HRP Conjugated
100µl   0.65mg/ml   $385.00
MAGOH Antibody - MAGOH antibody Western blot of MCF7 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human MAGOH
Xenopus, Chicken, Zebrafish, Drosophila, Rat, Hamster, Bat, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee
WB
Biotin Conjugated
100µl   1mg/ml   $385.00
MAGOH Antibody - MAGOH antibody Western blot of MCF7 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human MAGOH
Xenopus, Chicken, Zebrafish, Drosophila, Rat, Hamster, Bat, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee
WB
FITC Conjugated
100µl   1mg/ml   $385.00
MAGOH Antibody
Select
Rabbit Polyclonal to Human MAGOH
Human
WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $275.00
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).