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MAGED1 / NRAGE
melanoma antigen family D, 1
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
| Gene Name: | melanoma antigen family D, 1 |
| Synonyms: | MAGED1, DLXIN-1, MAGE-D1 antigen, Melanoma antigen family D, 1, NRAGE, MAGE tumor antigen CCF, Melanoma-associated antigen D1 |
| Target Sequences: | NM_006986 NP_008917.3 |
Publications (1)
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