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20700 44th Avenue W
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MAGEA1 / MAGE 1
melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. MAGE was originally isolated from human melanoma cells as an antigen that is recognizes by cytolytic T lymphocytes. It has since been documented in other carcinomas. In addition, expression has been documented in highly proliferating germ cells.
| Gene Name: | melanoma antigen family A, 1 (directs expression of antigen MZ2-E) |
| Synonyms: | MAGEA1, Antigen MZ2-E, Cancer/testis antigen 1.1, CT1.1, MAGE-1 antigen, MAGE1A, Melanoma antigen family A 1, Melanoma antigen MAGE-1, MAGE 1, MAGE1, Melanoma-associated antigen 1 |
| Target Sequences: | NM_004988 NP_004979.3 P43355 |
Publications (2)
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