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MAFA

v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A

Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.

Gene Name: v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
Synonyms: MAFA, HMafA, RIPE3b1, Transcription factor MafA, Transcription factor RIPE3b1
Target Sequences: NM_201589 NP_963883.2 Q8NHW3

Publications (1)

1
Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet ß-cell de-differentiation. Burke SJ, Batdorf HM, Burk DH, Martin TM, Mendoza T, Stadler K, Alami W, Karlstad MD, Robson MJ, Blakely RD, Mynatt RL, Collier JJ. Molecular metabolism. 2018 0;0:pii: S2212-8778(18)30304-1. (Mouse) [Full Text Article] [PubMed:29914854] [PMC:PMC6034063] Related Antibodies: LS-C286590.

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Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
MAFA (3)
No (3)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
MAFA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
36.8 kDa
20 µg/$150
MAFA Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
MAFA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
36.8 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).