Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells.
Gene Name: | microtubule-actin crosslinking factor 1 |
Synonyms: | MACF1, 620 kDa actin-binding protein, 620 kDa actin binding protein, ABP620, ACF7, KIAA1251, Macrophin 1, Macrophin-1, OFC4, KIAA0465, MACF, Trabeculin-alpha |
Target Sequences: | NM_012090 NP_036222.3 Q9UPN3 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.