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M6PR

mannose-6-phosphate receptor (cation dependent)

Targeting of newly synthesized lysosomal enzymes in many cell types depends on formation of mannose 6-phosphate residues on lysosomal enzymes and recognition of these residues by specific receptors. The cation-dependent mannose 6-phosphate receptor is one of the two transmembrane proteins involved in transport of lysosomal enzymes. Binding of ligands to this receptor is dependent on divalent cations and pH. This receptor is used for intracellular targeting but not for endocytosis of lysosomal enzymes. It is composed of two identical subunits.

Gene Name: mannose-6-phosphate receptor (cation dependent)
Synonyms: M6PR, CD-MPR, SMPR, MPR46, MPRD, Mr 46,000 Man6PR, CD Man-6-P receptor, MPR 46, MPR-46
Target Sequences: NM_002355 NP_002346.1 P20645

Publications (1)

1
Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons. Pearl P Y Lie, Dun-Sheng Yang, Philip Stavrides, Chris N Goulbourne, Ping Zheng, Panaiyur S Mohan, Anne M Cataldo, Ralph A Nixon. Cell reports. 2021 Apr;35:109034. [Full Text Article] [PubMed:33910020] [PMC:PMC8135226] Related Antibodies: LS-C94323.

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
M6PR (6)
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GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
M6PR Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
M6PR Protein - Purified recombinant protein M6PR was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
27.9 kDa
20 µg/$1,107
M6PR Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
30.99 kDa
100 µg/$494
M6PR Protein
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E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
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E. coli
GST
45.7 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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293T Cells
Myc-DDK (Flag)
30.99 kDa
20 µg/$150
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).