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LYVE1

lymphatic vessel endothelial hyaluronan receptor 1

Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

Gene Name: lymphatic vessel endothelial hyaluronan receptor 1
Synonyms: LYVE1, CRSBP-1, CRSBP1, Hyaluronic acid receptor, LYVE-1, XLKD1, HAR
Target Sequences: NM_006691 NP_006682.2

Publications (1)

1
Trafficking of a dual-modality magnetic resonance and fluorescence imaging superparamagnetic iron oxide-based nanoprobe to lymph nodes. Bumb A, Regino CA, Egen JG, Bernardo M, Dobson PJ, Germain RN, Choyke PL, Brechbiel MW. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2011 13:1163-72. (ICC, IHC-Fr; Mouse) [PubMed:21080233] [PMC:PMC3116972]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).