LYN

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.

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Products

Proteins (12)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Recombinant (8)

Target

LYN (12)

Publications

No (12)

Tag

10His, N-terminus + Myc, C-terminus (1)

6His, N-terminus (2)

GST (1)

GST, N-terminus (2)

His (1)

His, N-Terminal (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (10)

Mouse (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (4)

Insect Cells (1)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (1)

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Human LYN Protein (Recombinant His) - LS-G2139

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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LYN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124227

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.9 kDa

Price:

100 µg/$494

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Mouse LYN Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (Full Length) - LS-G137059

Source:

E. coli

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

63.7 kDa

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human LYN Protein (Recombinant GST, N-terminus) (aa413-512) - LS-G59149

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human LYN Protein (Recombinant GST, N-terminus) (Met1-Pro512) - LS-G140002

Source:

Insect Cells

Tag:

GST, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

84.8 kDa

Price:

50 µg/$707

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Human LYN Protein (Recombinant His, N-Terminal) - LS-G145279

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

26.5 kDa

Price:

50 µg/$419

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Human LYN Protein (Recombinant GST) (Full Length) - LS-G29230

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

81.95 kDa

Price:

10 µg/$479; 25 µg/$670

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Human LYN Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Gly2-Leu513) - LS-G26863

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

61 kDa

Price:

200 µl/$283

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Human LYN Protein (Over-Expression Lysate 6His, N-terminus) (Gly2-Leu513) - LS-G26727

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

61 kDa

Price:

100 µg/$298

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Human LYN Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67240

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.9 kDa

Price:

20 µg/$1,107

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Human LYN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79401

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.9 kDa

Price:

20 µg/$150

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Human LYN Protein (Recombinant His-T7) (aa263-491) - LS-G15786

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.2 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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