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LSM1
LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM1 is a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
| Gene Name: | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
| Synonyms: | LSM1, Cancer-associated Sm-like, Small nuclear ribonuclear CaSm, CASM, YJL124C |
| Target Sequences: | NM_014462 NP_055277.1 |
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