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LRWD1

leucine-rich repeats and WD repeat domain containing 1

Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.

Gene Name: leucine-rich repeats and WD repeat domain containing 1
Synonyms: LRWD1, Centromere protein 33, ORC-associated protein, ORCA, CENP-33
Target Sequences: NM_152892 NP_690852.1 Q9UFC0

☰ Filters
Products
Antibodies (11)
Primary (11)
LRWD1 (11)
Human (6)
Mouse (8)
Rat (1)
IHC (6)
WB (9)
ELISA (7)
ICC (1)
IF (1)
IP (1)
rabbit (11)
IgG (11)
polyclonal pc (11)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
PE Conjugated (1)
Unconjugated (6)
aa1-30 (6)
aa200-250 (1)
aa432-482 (1)
No (11)
Select
LRWD1 Rabbit anti-Human Polyclonal (aa1-30) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Select
LRWD1 Rabbit anti-Mouse Polyclonal (aa1-30) (Biotin) Antibody
Mouse
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Select
LRWD1 Rabbit anti-Mouse Polyclonal (aa1-30) (FITC) Antibody
Mouse
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
LRWD1 Rabbit anti-Mouse Polyclonal (aa1-30) (Azide-free) (HRP) Antibody
Mouse
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
LRWD1 Rabbit anti-Mouse Polyclonal (aa1-30) (APC) Antibody
Mouse
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
LRWD1 Rabbit anti-Mouse Polyclonal (aa1-30) (PE) Antibody
Mouse
ELISA, IHC, WB
PE Conjugated
200 µl/$952
LRWD1 Antibody - Immunofluorescence staining of LRWD1 in U2OS cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human LRWD1 polyclonal antibody (dilution ratio 1:200) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Nucleus and Cytoplasm.
Select
LRWD1 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF
Unconjugated
100 µl/$412
Select
LRWD1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$351
Select
LRWD1 Rabbit anti-Human Polyclonal (aa432-482) Antibody
Mouse, Human
WB
Unconjugated
10 µl/$295; 100 µl/$514
LRWD1 Antibody - Western blot analysis of extracts of various cell lines, using Lrwd1 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 5s.
Select
LRWD1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Select
LRWD1 Rabbit anti-Human Polyclonal (aa200-250) Antibody
Human
IP
Unconjugated
10 µg/$295; 100 µl/$514
Viewing 1-11 of 11 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).