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The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
Gene Name: | leucine rich repeat neuronal 2 |
Synonyms: | LRRN2, FIGLER7, Leucine rich repeat neuronal 2, GAC1, LRRN5, Leucine rich repeat neuronal 5, LRANK1 |
Target Sequences: | NM_006338 NP_006329.2 O75325 |
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