LRP4

low density lipoprotein receptor-related protein 4

Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

LRP4 (5)

Publications

No (5)

Tag

6His, N-terminus (1)

His (1)

His-GST (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Yeast (1)

Purification

Purified (1)

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LRP4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118049

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

211.9 kDa

Price:

100 µg/$710

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Human LRP4 Protein (Recombinant His) (aa1747-1905) - LS-G20937

Source:

E. coli

Tag:

His

Molecular Weight:

22 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human LRP4 Protein (Recombinant His-GST) (aa1610-1885) - LS-G25357

Source:

E. coli

Tag:

His-GST

Molecular Weight:

59.9 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Human LRP4 Protein (Recombinant 6His, N-terminus) (aa1747-1905) - LS-G57216

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$570; 20 µg/$395; 1 mg/$1,973

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Human LRP4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82116

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

211.9 kDa

Price:

20 µg/$215

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