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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
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LRP4
low density lipoprotein receptor-related protein 4
Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes.
| Gene Name: | low density lipoprotein receptor-related protein 4 |
| Synonyms: | LRP4, CLSS, LRP-4, SOST2, KIAA0816, MEGF7 |
| Target Sequences: | AA584297 O75096 O75096 |
![LRP4 Antibody - Western blot of rat brain membrane lysates showing the detection of ~215 kDa LRP4 protein using Anti-LRP4 antibody [S207-27] (LRP4 antibody). Lane 1: MW ladder. Lane 2: Anti-LRP4 (1:500). Lane 3: Anti-LRP4 (1:1000). Lane 4: Anti-LRP4 (1:2000). Load: 33 ug RBM per lane. Block: 5% milk + TBST O/N at 4°C. Primary antibody: Mouse Anti-LRP4 antibody [S207-27] (LRP4 antibody) at 1:500,1:1000 1:2000 dilution in TBS for 60 min at RT. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/lrp4-antibody-aa26-350-clone-s207-27-ls-c209514/156372_887832.jpg)
![LRP4 Antibody - Western blot of rat brain membrane lysates showing the detection of ~215 kDa LRP4 protein using Anti-LRP4 antibody [S207-27] (LRP4 antibody). Lane 1: MW ladder. Lane 2: Anti-LRP4 (1:500). Lane 3: Anti-LRP4 (1:1000). Lane 4: Anti-LRP4 (1:2000). Load: 33 ug RBM per lane. Block: 5% milk + TBST O/N at 4°C. Primary antibody: Mouse Anti-LRP4 antibody [S207-27] (LRP4 antibody) at 1:500,1:1000 1:2000 dilution in TBS for 60 min at RT. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/lrp4-antibody-aa26-350-clone-s207-27-biotin-ls-c228791/156372_887832.jpg)
![LRP4 Antibody - Western blot of rat brain membrane lysates showing the detection of ~215 kDa LRP4 protein using Anti-LRP4 antibody [S207-27] (LRP4 antibody). Lane 1: MW ladder. Lane 2: Anti-LRP4 (1:500). Lane 3: Anti-LRP4 (1:1000). Lane 4: Anti-LRP4 (1:2000). Load: 33 ug RBM per lane. Block: 5% milk + TBST O/N at 4°C. Primary antibody: Mouse Anti-LRP4 antibody [S207-27] (LRP4 antibody) at 1:500,1:1000 1:2000 dilution in TBS for 60 min at RT. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/lrp4-antibody-aa26-350-clone-s207-27-fitc-ls-c228792/156372_887832.jpg)
![LRP4 Antibody - Western blot of rat brain membrane lysates showing the detection of ~215 kDa LRP4 protein using Anti-LRP4 antibody [S207-27] (LRP4 antibody). Lane 1: MW ladder. Lane 2: Anti-LRP4 (1:500). Lane 3: Anti-LRP4 (1:1000). Lane 4: Anti-LRP4 (1:2000). Load: 33 ug RBM per lane. Block: 5% milk + TBST O/N at 4°C. Primary antibody: Mouse Anti-LRP4 antibody [S207-27] (LRP4 antibody) at 1:500,1:1000 1:2000 dilution in TBS for 60 min at RT. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/lrp4-antibody-aa26-350-clone-s207-27-ap-ls-c228790/156372_887832.jpg)
![LRP4 Antibody - Western blot of rat brain membrane lysates showing the detection of ~215 kDa LRP4 protein using Anti-LRP4 antibody [S207-27] (LRP4 antibody). Lane 1: MW ladder. Lane 2: Anti-LRP4 (1:500). Lane 3: Anti-LRP4 (1:1000). Lane 4: Anti-LRP4 (1:2000). Load: 33 ug RBM per lane. Block: 5% milk + TBST O/N at 4°C. Primary antibody: Mouse Anti-LRP4 antibody [S207-27] (LRP4 antibody) at 1:500,1:1000 1:2000 dilution in TBS for 60 min at RT. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/lrp4-antibody-aa26-350-clone-s207-27-atto-594-ls-c228784/156372_887832.jpg)
![LRP4 Antibody - Western blot of rat brain membrane lysates showing the detection of ~215 kDa LRP4 protein using Anti-LRP4 antibody [S207-27] (LRP4 antibody). Lane 1: MW ladder. Lane 2: Anti-LRP4 (1:500). Lane 3: Anti-LRP4 (1:1000). Lane 4: Anti-LRP4 (1:2000). Load: 33 ug RBM per lane. Block: 5% milk + TBST O/N at 4°C. Primary antibody: Mouse Anti-LRP4 antibody [S207-27] (LRP4 antibody) at 1:500,1:1000 1:2000 dilution in TBS for 60 min at RT. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/lrp4-antibody-aa26-350-clone-s207-27-atto-488-ls-c228782/156372_887832.jpg)
![LRP4 Antibody - Western blot of rat brain membrane lysates showing the detection of ~215 kDa LRP4 protein using Anti-LRP4 antibody [S207-27] (LRP4 antibody). Lane 1: MW ladder. Lane 2: Anti-LRP4 (1:500). Lane 3: Anti-LRP4 (1:1000). Lane 4: Anti-LRP4 (1:2000). Load: 33 ug RBM per lane. Block: 5% milk + TBST O/N at 4°C. Primary antibody: Mouse Anti-LRP4 antibody [S207-27] (LRP4 antibody) at 1:500,1:1000 1:2000 dilution in TBS for 60 min at RT. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/lrp4-antibody-aa26-350-clone-s207-27-atto-390-ls-c228781/156372_887832.jpg)
![LRP4 Antibody - Western blot of rat brain membrane lysates showing the detection of ~215 kDa LRP4 protein using Anti-LRP4 antibody [S207-27] (LRP4 antibody). Lane 1: MW ladder. Lane 2: Anti-LRP4 (1:500). Lane 3: Anti-LRP4 (1:1000). Lane 4: Anti-LRP4 (1:2000). Load: 33 ug RBM per lane. Block: 5% milk + TBST O/N at 4°C. Primary antibody: Mouse Anti-LRP4 antibody [S207-27] (LRP4 antibody) at 1:500,1:1000 1:2000 dilution in TBS for 60 min at RT. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/lrp4-antibody-aa26-350-clone-s207-27-apc-ls-c228789/156372_887832.jpg)
![LRP4 Antibody - Western blot of rat brain membrane lysates showing the detection of ~215 kDa LRP4 protein using Anti-LRP4 antibody [S207-27] (LRP4 antibody). Lane 1: MW ladder. Lane 2: Anti-LRP4 (1:500). Lane 3: Anti-LRP4 (1:1000). Lane 4: Anti-LRP4 (1:2000). Load: 33 ug RBM per lane. Block: 5% milk + TBST O/N at 4°C. Primary antibody: Mouse Anti-LRP4 antibody [S207-27] (LRP4 antibody) at 1:500,1:1000 1:2000 dilution in TBS for 60 min at RT. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/lrp4-antibody-aa26-350-clone-s207-27-percp-ls-c228795/156372_887832.jpg)
![LRP4 Antibody - Western blot of rat brain membrane lysates showing the detection of ~215 kDa LRP4 protein using Anti-LRP4 antibody [S207-27] (LRP4 antibody). Lane 1: MW ladder. Lane 2: Anti-LRP4 (1:500). Lane 3: Anti-LRP4 (1:1000). Lane 4: Anti-LRP4 (1:2000). Load: 33 ug RBM per lane. Block: 5% milk + TBST O/N at 4°C. Primary antibody: Mouse Anti-LRP4 antibody [S207-27] (LRP4 antibody) at 1:500,1:1000 1:2000 dilution in TBS for 60 min at RT. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/lrp4-antibody-aa26-350-clone-s207-27-rpe-ls-c228797/156372_887832.jpg)
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