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LPXN / Leupaxin

Leupaxin

Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.

Gene Name:	Leupaxin
Synonyms:	LPXN, LDLP, Leupaxin, LDPL
Target Sequences:	NM_004811 NP_004802.1 O60711

Publications (1)

Protein tyrosine kinase 2b inhibition reverts niche-associated resistance to tyrosine kinase inhibitors in AML. Catana Allert, Alexander Waclawiczek , Sarah Miriam Naomi Zimmermann , Stefanie Göllner, Daniel Heid, Maike Janssen, Simon Renders, Christian Rohde, Marcus Bauer, Margarita Bruckmann, Rafael Zinz, Cornelius Pauli, Birgit Besenbeck, Claudia Wickenhauser, Andreas Trumpp, Jeroen Krijgsveld, Carsten Müller-Tidow, Maximilian Felix Blank. Leukemia. 2022 October;36:2418-2429. [Full Text Article] [PubMed:36056084] [PMC:PMC9522596] Related Antibodies: LS-C313296.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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