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LPCAT2
lysophosphatidylcholine acyltransferase 2
Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine.
| Gene Name: | lysophosphatidylcholine acyltransferase 2 |
| Synonyms: | LPCAT2, AYTL1, Acyltransferase like 1, Acyltransferase-like 1, LPCAT-2, Lyso-PAF acetyltransferase, LysoPC acyltransferase 2, LPC acyltransferase 2, LysoPAFAT |
| Target Sequences: | NM_017839 NP_060309.2 Q7L5N7 |
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