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LOX / Lysyl Oxidase

lysyl oxidase

Lysyl Oxidase / LOX is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.

Gene Name:	lysyl oxidase
Synonyms:	LOX, Lysyl oxidase, Protein-lysine 6-oxidase
Target Sequences:	NM_002317 NP_002308.2 P28300

Publications (16)

Lysyl oxidase inhibits ras-mediated transformation by preventing activation of NF-kappa B. Jeay S, Pianetti S, Kagan HM, Sonenshein GE. Molecular and cellular biology. 2003 23:2251-63. [PubMed:12640111] [PMC:PMC150722]

The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells. Palamakumbura AH, Jeay S, Guo Y, Pischon N, Sommer P, Sonenshein GE, Trackman PC. The Journal of biological chemistry. 2004 279:40593-600. [PubMed:15277520]

Tumor suppressive effect of lysyl oxidase proenzyme. Contente S, Yeh TJ, Friedman RM. Biochimica et biophysica acta. 2009 1793:1272-8. [PubMed:19410608]

Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase. Horiguchi M, Inoue T, Ohbayashi T, Hirai M, Noda K, Marmorstein LY, Yabe D, Takagi K, Akama TO, Kita T, Kimura T, Nakamura T. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:19029-34. [PubMed:19855011] [PMC:PMC2776456]

Induction of cardiac fibroblast lysyl oxidase by TGF-1 requires PI3K/Akt, Smad3, and MAPK signaling. Voloshenyuk TG, Landesman ES, Khoutorova E, Hart AD, Gardner JD. Cytokine. 2011 55:90-7. (WB; Rat) [PubMed:21498085]

The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells. Sato S, Trackman PC, Mki JM, Myllyharju J, Kirsch KH, Sonenshein GE. Molecular and cellular biology. 2011 31:2683-95. [PubMed:21536655] [PMC:PMC3133379]

Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells. Sethi A, Mao W, Wordinger RJ, Clark AF. Investigative ophthalmology & visual science. 2011 52:5240-50. [PubMed:21546528] [PMC:PMC3176072]

The lysyl oxidase propeptide interacts with the receptor-type protein tyrosine phosphatase kappa and inhibits -catenin transcriptional activity in lung cancer cells. Snchez-Morgan N, Kirsch KH, Trackman PC, Sonenshein GE. Molecular and cellular biology. 2011 31:3286-97. [PubMed:21690299] [PMC:PMC3147807]

Copper deficiency induced emphysema is associated with focal adhesion kinase inactivation. Mizuno S, Yasuo M, Bogaard HJ, Kraskauskas D, Alhussaini A, Gomez-Arroyo J, Farkas D, Farkas L, Voelkel NF. PloS one. 2012 7:e30678. [PubMed:22276220] [PMC:PMC3262830]

Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenografts. Bais MV, Nugent MA, Stephens DN, Sume SS, Kirsch KH, Sonenshein GE, Trackman PC. PloS one. 2012 7:e31188. [PubMed:22363577] [PMC:PMC3280126]

A new model of experimental fibrosis in hindlimb skeletal muscle of adult mdx mouse mimicking muscular dystrophy. Desguerre I, Arnold L, Vignaud A, Cuvellier S, Yacoub-Youssef H, Gherardi RK, Chelly J, Chretien F, Mounier R, Ferry A, Chazaud B. Muscle & nerve. 2012 45:803-14. (IHC; Mouse) [PubMed:22581532]

The role of lysyl oxidase family members in the stabilization of abdominal aortic aneurysms. Remus EW, O'Donnell RE, Rafferty K, Weiss D, Joseph G, Csiszar K, Fong SF, Taylor WR. American journal of physiology. Heart and circulatory physiology. 2012 303:H1067-75. (WB; Mouse) [PubMed:22904155] [PMC:PMC3469640]

Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas. Dudakova L, Liskova P, Trojek T, Palos M, Kalasova S, Jirsova K. Experimental eye research. 2012 104:74-81. (ICC, IHC-Fr; Human) [PubMed:23041260]

Insight On Colorectal Carcinoma Infiltration by Studying Perilesional Extracellular Matrix. Nebuloni M, Albarello L, Andolfo A, Magagnotti C, Genovese L, Locatelli I, Tonon G, Longhi E, Zerbi P, Allevi R, Podestà A, Puricelli L, Milani P, Soldarini A, Salonia A, Alfano M. Scientific reports. 2016 6:22522. (WB; Human) [Full Text Article] [PubMed:26940881] [PMC:PMC4778019] Related Antibodies: LS-C114933.

Intracellular Role for the Matrix-Modifying Enzyme Lox in Regulating Transcription Factor Subcellular Localization and Activity in Muscle Regeneration. Ravit Gabay Yehezkely, Shelly Zaffryar-Eilot, Anna Kaganovsky, Nurit Fainshtain Malka, Rohtem Aviram, Ido Livneh, Peleg Hasson. Developmental cell. 2020 May;53:406-417.e5. [Full Text Article] [PubMed:32359406]

Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families. Rohtem Aviram, Shelly Zaffryar-Eilot, Dirk Hubmacher, Hagar Grunwald, Joni M Mäki, Johanna Myllyharju, Suneel S Apte, Peleg Hasson. Matrix biology : journal of the International Society for Matrix Biology. 2019 Jan;75-76:114-125. [Full Text Article] [PubMed:29758265] [PMC:PMC6240406]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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