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LNX1 / LNX
ligand of numb-protein X 1, E3 ubiquitin protein ligase
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.
| Gene Name: | ligand of numb-protein X 1, E3 ubiquitin protein ligase |
| Synonyms: | LNX1, Ligand of numb-protein X, LNX, Ligand of Numb-protein X 1, Numb-binding protein 1, PDZRN2 |
| Target Sequences: | NM_032622 NP_116011.2 Q8TBB1 |
Publications (1)
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