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LNX1 / LNX
ligand of numb-protein X 1, E3 ubiquitin protein ligase
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.
| Gene Name: | ligand of numb-protein X 1, E3 ubiquitin protein ligase |
| Synonyms: | LNX1, Ligand of numb-protein X, LNX, Ligand of Numb-protein X 1, Numb-binding protein 1, PDZRN2 |
| Target Sequences: | NM_032622 NP_116011.2 Q8TBB1 |
Publications (1)
1
Positive feedback of SuFu negating protein 1 on Hedgehog signaling promotes colorectal tumor growth10<sup> Center for Experimental Medicine, The First Affiliated Hospital of Nanchang University, 330006, Nanchang, Jiangxi, China. shiwenluo@ncu.edu.cn. Zhengwei Yan #, Minzhang Cheng #, Guohui Hu #, Yao Wang , Shaopeng Zeng, Aidi Huang, Linlin Xu, Yuan Liu, Chao Shi, Libin Deng, Quqin Lu, Hai Rao, Hua Lu , Ye-Guang Chen, Shiwen Luo. Cell death & disease. 2021 Feb;12:199. [Full Text Article]
[PubMed:33608498]
[PMC:PMC7896051]
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(24)
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(24)
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(2)
Target
LNX1 / LNX
(28)
Reactivity
Human
(24)
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(4)
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(3)
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(3)
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(3)
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(3)
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(17)
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(11)
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(2)
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(1)
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(14)
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(9)
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(1)
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(2)
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(13)
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(2)
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(6)
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monoclonal mc
(8)
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(16)
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(2)
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(1)
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(3)
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(1)
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(3)
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(3)
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(1)
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(13)
Epitope
aa431-480
(4)
aa19-119
(1)
aa260-528
(1)
aa274-285
(1)
Publications
No
(28)
Tag
GST
(1)
GST, N-terminus
(1)
Myc-DDK (Flag)
(2)
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Human
(3)
Source
293T Cells
(1)
HEK 293 Cells
(1)
Wheat Germ Extract
(2)
Purification
Purified
(1)
LNX1 / LNX Mouse anti-Human Monoclonal (1H9) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
LNX1 / LNX Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-P
Unconjugated
50 µl/$460
LNX1 / LNX Goat anti-Human Polyclonal (aa274-285) Antibody
Human
Peptide-ELISA
Unconjugated
100 µg/$384
LNX1 / LNX Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
LNX1 / LNX Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
LNX1 / LNX Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
LNX1 / LNX Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
LNX1 / LNX Mouse anti-Human Monoclonal (aa19-119) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
LNX1 / LNX Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$904
LNX1 / LNX Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$904
LNX1 / LNX Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$904
LNX1 / LNX Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$904
LNX1 / LNX Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$904
LNX1 / LNX Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
LNX1 / LNX Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
LNX1 / LNX Mouse anti-Human Monoclonal (aa260-528) (Carrier-free) (1H9) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
LNX1 / LNX Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$466
LNX1 / LNX Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$466
LNX1 / LNX Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
LNX1 / LNX Rabbit anti-Human Polyclonal (aa431-480) Antibody
Human
WB
Unconjugated
100 µl/$397
LNX1 / LNX Rabbit anti-Human Polyclonal (aa431-480) (HRP) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100 µl/$442
LNX1 / LNX Rabbit anti-Human Polyclonal (aa431-480) (Biotin) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100 µl/$442
LNX1 / LNX Rabbit anti-Human Polyclonal (aa431-480) (FITC) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100 µl/$442
LNX1 / LNX Mouse anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µg/$705
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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