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LMNA / Lamin A+C

lamin A/C

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Gene Name: lamin A/C
Synonyms: LMNA, 70 kDa lamin, CDCD1, CMD1A, EMD2, FPLD, IDC, FPL, FPLD2, Lamin A/C, Lamin, LFP, LMNC, LMN1, LMNL1, HGPS, Prelamin-A/C, PRO1, Lamin A, Lamin A/C-like 1, LGMD1B, CDDC, CMT2B1, LDP1
Target Sequences: NM_005572 NP_005563.1 P02545

Publications (5)

1
Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells. Zhang Y, Wang Z, Magnuson NS. Molecular cancer research : MCR. 2007 5:909-22. [PubMed:17855660] Related Antibodies: LS-B2005.
2
Meiotic chromosome pairing and bouquet formation during Eimeria tenella sporulation. del Cacho E, Pags M, Gallego M, Barbero JL, Monteagudo L, Snchez-Acedo C. International journal for parasitology. 2010 40:453-62. (WB, IHC-Fr; Eimeria tenella) [PubMed:19837073] Related Antibodies: LS-C25073.
3
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain. Takezaki S, Yamada M, Kato M, Park MJ, Maruyama K, Yamazaki Y, Chida N, Ohara O, Kobayashi I, Ariga T. Journal of immunology (Baltimore, Md. : 1950). 2012 189:1521-6. [PubMed:22730530] Related Antibodies: LS-B2005.
4
The Cardiomyopathy Lamin A/C D192G Mutation Disrupts Whole-Cell Biomechanics in Cardiomyocytes as Measured by Atomic Force Microscopy Loading-Unloading Curve Analysis. Lanzicher T, Martinelli V, Puzzi L, Del Favero G, Codan B, Long CS, Mestroni L, Taylor MR, Sbaizero O. Scientific reports. 2015 5:13388. (ICC; Human) [Full Text Article] [PubMed:26323789] [PMC:PMC4555041]
5
AFM single-cell force spectroscopy links altered nuclear and cytoskeletal mechanics to defective cell adhesion in cardiac myocytes with a nuclear lamin mutation. Lanzicher T, Martinelli V, Long CS, Del Favero G, Puzzi L, Borelli M, Mestroni L, Taylor MR, Sbaizero O. Nucleus (Austin, Tex.). 2015 6:394-407. (ICC; Human) [Full Text Article] [PubMed:26309016] [PMC:PMC4915516]
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LMNA / Lamin A+C (10)
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LMNA / Lamin A+C Protein - Recombinant  Lamin A/C By SDS-PAGE
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E. coli
His-T7
52.2 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
LMNA / Lamin A+C Protein - Purified recombinant protein LMNA was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
74 kDa
20 µg/$1,107
LMNA / Lamin A+C Protein - Purified recombinant protein LMNA was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
65 kDa
20 µg/$1,107
LMNA / Lamin A+C Protein - 12.5% SDS-PAGE of human LMNA stained with Coomassie Blue
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Wheat Germ Extract
GST
100.5 kDa
2 µg/$439
LMNA / Lamin A+C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
74 kDa
100 µg/$494
LMNA / Lamin A+C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
70.5 kDa
100 µg/$710
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293T Cells
Myc-DDK (Flag)
65 kDa
20 µg/$150
LMNA / Lamin A+C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
70.5 kDa
20 µg/$215
LMNA / Lamin A+C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
74 kDa
20 µg/$150
LMNA / Lamin A+C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
65 kDa
100 µg/$494
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).