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B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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LMCD1
LIM and cysteine-rich domains 1
Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
| Gene Name: | LIM and cysteine-rich domains 1 |
| Synonyms: | LMCD1, Dyxin |
| Target Sequences: | NM_014583 NP_055398.1 Q9NZU5 |
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