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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
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Additional Contact Details
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LITAF
lipopolysaccharide-induced TNF factor
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene.
| Gene Name: | lipopolysaccharide-induced TNF factor |
| Synonyms: | LITAF, PIG7, TP53I7, p53-induced gene 7 protein, SIMPLE, CMT1C, LPS-induced TNF-alpha factor |
| Target Sequences: | NM_004862 NP_004853.2 Q99732 |
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