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Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.
Gene Name: | leucine rich repeat and Ig domain containing 1 |
Synonyms: | LINGO1, LERN1, LRRN6A, UNQ201 |
Target Sequences: | NM_032808 NP_116197.4 Q96FE5 |
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