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LIN7C / VELI3

lin-7 homolog C (C. elegans)

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Gene Name: lin-7 homolog C (C. elegans)
Synonyms: LIN7C, LIN-7 protein 3, LIN-7-C, VELI3, Protein lin-7 homolog C, Vertebrate lin-7 homolog 3, Lin-7 homolog C (C. elegans), LIN-7C, MALS-3, MALS3, Mammalian lin-seven protein 3, Veli-3
Target Sequences: NM_018362 NP_060832.1 Q9NUP9

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
LIN7C / VELI3 (5)
No (5)
GST (1)
His (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
LIN7C / VELI3 Protein - Purified recombinant protein LIN7C was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
21.7 kDa
20 µg/$1,107
LIN7C / VELI3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
21.7 kDa
20 µg/$150
LIN7C / VELI3 Protein - 12.5% SDS-PAGE of human LIN7C stained with Coomassie Blue
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Wheat Germ Extract
GST
48.2 kDa
10 µg/$479; 25 µg/$670
LIN7C / VELI3 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
LIN7C / VELI3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
21.7 kDa
100 µg/$494
Viewing 1-5 of 5 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).