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LIN54
lin-54 homolog (C. elegans)
Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner.
| Gene Name: | lin-54 homolog (C. elegans) |
| Synonyms: | LIN54, CXC domain containing 1, CXCDC1, MIP120, JC8.6, KIAA2037, Protein lin-54 homolog, Lin-54 homolog (C. elegans) |
| Target Sequences: | NM_001115007 NP_001108479.1 Q6MZP7 |
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