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LIN28B
lin-28 homolog B (C. elegans)
Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.
| Gene Name: | lin-28 homolog B (C. elegans) |
| Synonyms: | LIN28B, CSDD2, Lin-28B, Lin-28 homolog B (C. elegans), Protein lin-28 homolog B, Lin-28.2 |
| Target Sequences: | NP_001004317.1 Q6ZN17 |
Publications (2)
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