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LIMS1 / PINCH is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
Gene Name: | LIM and senescent cell antigen-like domains 1 |
Synonyms: | LIMS1, PINCH, PINCH-1, PINCH1 |
Target Sequences: | NM_004987 NP_004978.2 P48059 |
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