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LIMK1 / LIMK

LIM domain kinase 1

Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).

Gene Name: LIM domain kinase 1
Family/Subfamily: Protein Kinase , LIMK
Synonyms: LIMK1, LIM domain kinase 1, Lim kinase 1, LIMK-1, LIM kinase, LIMK
Target Sequences: NM_002314 NP_002305.1 P53667

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Products
Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
LIMK1 / LIMK (5)
No (5)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
LIMK1 / LIMK Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
LIMK1 / LIMK Protein - 12.5% SDS-PAGE of human LIMK1 stained with Coomassie Blue
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Wheat Germ Extract
GST
96.8 kDa
2 µg/$439
LIMK1 / LIMK Protein - Purified recombinant protein LIMK1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
72.4 kDa
20 µg/$1,107
LIMK1 / LIMK Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
72.4 kDa
20 µg/$215
LIMK1 / LIMK Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
72.4 kDa
100 µg/$710
Viewing 1-5 of 5 product results


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Products: Proteins


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).