LIMK1 / LIMK

LIM domain kinase 1

Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).

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Products

ELISA Kits (4)

Type

Cell-Based (2)

Cell-Based Phosphorylation (1)

Sandwich (1)

Target

LIMK1 / LIMK (4)

Reactivity

Human (4)

Mouse (3)

Rat (3)

Format

96-Well Microplate (3)

96-Well Strip Plate (1)

Publications

No (4)

Sample Type

Adherent Cell Cultures (3)

Plasma (1)

Serum (1)

Tissue Homogenates (1)

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Human LIMK1 / LIMK (Sandwich ELISA) ELISA Kit - LS-F56212

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse/Human/Rat Phospho-LIMK1 / LIMK (Thr508) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1554

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat LIMK1 / LIMK (Cell-Based ELISA) ELISA Kit - LS-F3130

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Mouse/Human/Rat LIMK1 / LIMK (Cell-Based ELISA) ELISA Kit - LS-F2118

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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