LIMK1 / LIMK

LIM domain kinase 1

Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).

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Products

Antibodies (87)

Proteins (5)

ELISA Kits (4)

Type

Cell-Based (2)

Cell-Based Phosphorylation (1)

Over-Expression Lysate (2)

Primary (87)

Recombinant (3)

Sandwich (1)

Target

LIMK1 / LIMK (96)

Reactivity

Human (88)

Mouse (42)

Rat (33)

Chicken (2)

Chimpanzee (1)

Dog (4)

Horse (2)

Monkey (4)

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Application

IHC (37)

IHC-P (16)

WB (72)

Flo (18)

DB (7)

ELISA (31)

ICC (1)

IF (30)

IP (5)

Peptide-ELISA (7)

Host

rabbit (61)

mouse (26)

Product Group

IHCPlus (3)

Isotype

IgG (49)

IgG1,k (3)

IgG2a (10)

IgG2a,k (2)

IgG2b (10)

Clonality

monoclonal mc (26)

polyclonal pc (61)

Clone

175CT3.2.5 (1)

1A8 (1)

1B2 (1)

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OTI 7C3 (2)

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96-Well Microplate (3)

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Unconjugated (69)

Epitope

pThr508 (19)

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440-520 aa (2)

aa479-508 (2)

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aa461-510 (1)

aa471-520 (1)

aa548-648 (1)

aa597-647 (1)

aa599-634 (1)

aa620-647 (1)

p508 (1)

pThr508,pThr505 (1)

pThr508/505 (1)

pTyr507/Thr508/Tyr504/Thr505 (1)

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Publications

No (96)

Sample Type

Adherent Cell Cultures (3)

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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IHC-plus™ LIMK1 / LIMK Antibody (clone 1A8) LS-B5430

(4.0) Rating

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (1A8) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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Human LIMK1 / LIMK (Sandwich ELISA) ELISA Kit - LS-F56212

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse/Human/Rat Phospho-LIMK1 / LIMK (Thr508) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1554

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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LIMK1 / LIMK Antibody (clone OTI6B4) LS-C173012

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (OTI6B4) Antibody

Reactivity:

Mouse, Dog, Rat, Human, Monkey

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

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LIMK1 / LIMK Antibody (clone OTI6B4, Carrier-free) LS-C786090

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (Carrier-free) (OTI6B4) Antibody

Reactivity:

Mouse, Dog, Rat, Human, Monkey

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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IHC-plus™ LIMK1 / LIMK Antibody (clone 2E9) LS-B5431

(4.0) Rating

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (2E9) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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LIMK1 / LIMK Antibody (phospho-Thr508) LS-C826307

Antibody:

LIMK1 / LIMK Rabbit anti-Human Polyclonal (pThr508) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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LIMK1 / LIMK Antibody (aa479-508, clone 175CT3.2.5) LS-C319170

Antibody:

LIMK1 / LIMK Mouse anti-Mouse Monoclonal (aa479-508) (175CT3.2.5) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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LIMK1 / LIMK Antibody (clone OTI2A11) LS-C173082

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (OTI2A11) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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LIMK1 / LIMK Antibody (clone OTI2A11, Carrier-free) LS-C786181

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (Carrier-free) (OTI2A11) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

LIMK1 / LIMK Antibody (clone OTI8C8) LS-C172997

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (OTI8C8) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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LIMK1 / LIMK Antibody (clone OTI8C8, Carrier-free) LS-C786071

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (Carrier-free) (OTI8C8) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

LIMK1 / LIMK Antibody (clone OTI3H6) LS-C172767

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (OTI3H6) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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LIMK1 / LIMK Antibody (clone OTI3H6, Carrier-free) LS-C786004

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (Carrier-free) (OTI3H6) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

IHC-plus™ LIMK1 / LIMK Antibody (aa597-647) LS-B15073

(4.0) Rating

Antibody:

LIMK1 / LIMK Rabbit anti-Human Polyclonal (aa597-647) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$485

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LIMK1 / LIMK Antibody (phospho-Thr508,pThr505) LS-C801113

Antibody:

LIMK1 / LIMK Rabbit anti-Human Polyclonal (pThr508,pThr505) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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LIMK1 / LIMK Antibody (phospho-Thr508) LS-C801116

Antibody:

LIMK1 / LIMK Rabbit anti-Human Polyclonal (pThr508) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

LIMK1 / LIMK Antibody (clone OTI3G3) LS-C172995

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (OTI3G3) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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LIMK1 / LIMK Antibody (clone OTI3G3, Carrier-free) LS-C786069

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (Carrier-free) (OTI3G3) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

LIMK1 / LIMK Antibody (440-520 aa) LS-C380762

Antibody:

LIMK1 / LIMK Rabbit anti-Human Polyclonal (440-520 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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LIMK1 / LIMK Antibody LS-C801613

Antibody:

LIMK1 / LIMK Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

LIMK1 / LIMK Antibody (phospho-Thr508) LS-C177920

Antibody:

LIMK1 / LIMK Rabbit anti-Human Polyclonal (pThr508) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$328; 100 µl/$419

Select

LIMK1 / LIMK Antibody (Gln491) LS-C176780

Antibody:

LIMK1 / LIMK Rabbit anti-Human Polyclonal (Gln491) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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LIMK1 / LIMK Antibody (clone OTI1F1) LS-C173111

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (OTI1F1) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

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LIMK1 / LIMK Antibody (clone OTI3A3) LS-C173129

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (OTI3A3) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

Viewing 1-25 of 96 product results

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