LIMD1

LIM domains containing 1

Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

LIMD1 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human LIMD1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89905

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72 kDa

Price:

20 µg/$215

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LIMD1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114078

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72 kDa

Price:

100 µg/$710

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Human LIMD1 Protein (Recombinant GST) (Full Length) - LS-G31424

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

98.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human LIMD1 Protein (Recombinant GST, N-terminus) (aa577-674) - LS-G60947

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human LIMD1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71489

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72 kDa

Price:

20 µg/$1,107

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