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LILRB2 / ILT4

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2

LILRB2 / ILT4 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
Family/Subfamily: Immunoglobulin , not assigned-Immunoglobulin
Synonyms: LILRB2, CD85D, CD85d antigen, Ig-like transcript 4, LIR-2, MIR-10, MIR10, ILT-4, ILT4, LIR2
Target Sequences: NM_005874 NP_005865.3 Q8N423

Publications (1)

1
Heterogeneity in tertiary lymphoid structure B-cells correlates with patient survival in metastatic melanoma. Kevin T Lynch, Samuel J Young, Max O Meneveau, Nolan A Wages, Victor H Engelhard, Craig L Slingluff Jr, Ileana S Mauldin. Journal for immunotherapy of cancer. 2021 June;9: [Full Text Article] [PubMed:34103353] [PMC:PMC8190052] Related Antibodies: LS-B9762.

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Products
Antibodies (33)
Primary (33)
LILRB2 / ILT4 (33)
Human (33)
Mouse (12)
Rat (3)
IHC (7)
IHC-P (7)
WB (26)
Flo (6)
ELISA (6)
Peptide-ELISA (1)
rabbit (26)
mouse (7)
Product Group
IHCPlus (3)
IgG (13)
IgG2a (2)
IgG2b (1)
monoclonal mc (7)
polyclonal pc (26)
01 (1)
11 (4)
2G7E11 (1)
APC (1)
APC Conjugated (3)
Biotin Conjugated (3)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (4)
HRP Conjugated (3)
PE Conjugated (4)
Unconjugated (14)
aa53-255 (8)
C-Terminus (4)
121-170 aa, Internal (1)
No (32)
Yes (1)
LILRB2 / ILT4 Antibody - Anti-LILRB2 / ILT4 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
LILRB2 / ILT4 Antibody - Anti-LILRB2 / ILT4 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
LILRB2 / ILT4 Antibody - Anti-LILRB2 / ILT4 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
LILRB2 / ILT4 Antibody - Anti-LILRB2 / ILT4 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
LILRB2 / ILT4 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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LILRB2 / ILT4 Mouse anti-Human Monoclonal (2G7E11) Antibody
Human
ELISA, Flo, IHC-P, WB
Unconjugated
0.05 mg/$460
LILRB2 / ILT4 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
LILRB2 / ILT4 Antibody - Western blot of LILRB2 / ILT4 antibody.
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal (aa53-255) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
LILRB2 / ILT4 Antibody - Western blot of LILRB2 / ILT4 antibody.
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal (aa53-255) (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
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LILRB2 / ILT4 Mouse anti-Human Monoclonal (PE) Antibody
Human
Flo
PE Conjugated
100 Tests/$802
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LILRB2 / ILT4 Mouse anti-Human Monoclonal (11) Antibody
Human
ELISA, Flo
Unconjugated
20 µl/$271; 100 µl/$412
LILRB2 / ILT4 Antibody - 1:100 staining human lymph node tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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LILRB2 / ILT4 Mouse anti-Human Monoclonal (FITC) (11) Antibody
Human
Flo
FITC Conjugated
25 Tests/$278; 100 Tests/$346
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
LILRB2 / ILT4 Antibody - Western blot of CD85d antibody
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal (121-170 aa, Internal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
LILRB2 / ILT4 Antibody - Western Blot analysis of extracts from Hela cells using LILRB2 Antibody.
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
LILRB2 / ILT4 Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
50 µl/$460
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LILRB2 / ILT4 Mouse anti-Human Monoclonal (01) Antibody
Human
ELISA
Unconjugated
100 µl/$412
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LILRB2 / ILT4 Mouse anti-Human Monoclonal (PE) (11) Antibody
Human
Flo
PE Conjugated
25 Tests/$293; 100 Tests/$376
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LILRB2 / ILT4 Mouse anti-Human Monoclonal (APC) (11) Antibody
Human
Flo
APC Conjugated
25 Tests/$293; 100 Tests/$376
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$937
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$937
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal (PE) Antibody
Human
WB
PE Conjugated
100 µl/$937
LILRB2 / ILT4 Antibody - Western blot analysis of extracts of various cell lines, using LILRB2 antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 5s.
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
LILRB2 / ILT4 Antibody - Western blot analysis of extracts of various cell lines using LILRB2 Polyclonal Antibody at dilution of 1:3000.
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LILRB2 / ILT4 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).