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LILRA4 / ILT7

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4

ILT7 / LILRA4 is an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4.

Gene Name:	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
Synonyms:	LILRA4, CD85g antigen, CD85g, ILT7, ILT-7
Target Sequences:	IPI00017501.1 P59901

Publications (1)

Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients. Jensen MA, Patterson KC, Kumar AA, Kumabe M, Franek BS, Niewold TB. Annals of the rheumatic diseases. 2013 72:596-601. [PubMed:22904259]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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