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LIG3 / DNA Ligase III
ligase III, DNA, ATP-dependent
LIG3 / DNA Ligase III is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.
| Gene Name: | ligase III, DNA, ATP-dependent |
| Synonyms: | LIG3, DNA ligase III, Ligase II, DNA, ATP-dependent, LIG2, Ligase III, DNA, ATP-dependent, DNA ligase 3 |
| Target Sequences: | NM_013975 NP_039269.2 P49916 |
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