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LGALS9 / Galectin 9
lectin, galactoside-binding, soluble, 9
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS9 is an S-type lectin. This galectin is strongly overexpressed in Hodgkin's disease tissue and it might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its consistently associated immunodeficiency. The protein has N- and C- terminal carbohydrate-binding domains connected by a link peptide. Two isoforms (long and short) exist.
| Gene Name: | lectin, galactoside-binding, soluble, 9 |
| Synonyms: | LGALS9, Gal-9, HUAT, Galectin 9, Galectin-9, LGALS9A, Tumor antigen HOM-HD-21, Ecalectin |
| Target Sequences: | NM_009587 NP_033665.1 O00182 |
Publications (3)
1
Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals. Thomas A Premeaux, Michelle L D'Antoni, Mohamed Abdel-Mohsen, Satish K Pillai, Kalpana J Kallianpur, Beau K Nakamoto, Melissa Agsalda-Garcia, Bruce Shiramizu, Cecilia M Shikuma, Magnus Gisslén, Richard W Price, Victor Valcour, Lishomwa C Ndhlovu. Journal of neurovirology. 2019 April;25:150-161. [Full Text Article]
[PubMed:30478799]
[PMC:PMC6506351]
Related Antibodies: LS-B12783.
2
Targeting the C-terminus of galectin-9 induces mesothelioma apoptosis and M2 macrophage depletion. Pietro Bertino, Thomas A Premeaux, Tsuyoshi Fujita, Brien K Haun, Michael P Marciel, Fukun W Hoffmann, Alan Garcia, Haining Yiang, Sandra Pastorino, Michele Carbone, Toshiro Niki, John Berestecky, Peter R Hoffmann, Lishomwa C Ndhlovu. Oncoimmunology. 2019 Apr;8:1601482. [Full Text Article]
[PubMed:31413910]
[PMC:PMC6682368]
Related Antibodies: LS-B6275.
3
The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer. William A Freed-Pastor, Laurens J Lambert, Zackery A Ely, Nimisha B Pattada, Arjun Bhutkar, George Eng, Kim L Mercer, Ana P Garcia, Lin Lin, William M Rideout rd, William L Hwang, Jason M Schenkel, Alex M Jaeger, Roderick T Bronson, Peter M K Westcott, Tyler D Hether, Prajan Divakar, Jason W Reeves, Vikram Deshpande, Toni Delorey, Devan Phillips, Omer H Yilmaz, Aviv Regev, Tyler Jacks. Cancer cell. 2021 October;39:1342-1360.e14. [Full Text Article]
[PubMed:34358448]
[PMC:PMC8511341]
Related Antibodies: LS-B6275.
☰ Filters
Products
Proteins
(24)
Type
Over-Expression Lysate
(2)
Recombinant
(22)
Target
LGALS9 / Galectin 9
(24)
Publications
No
(24)
Tag
6His, C-terminus
(2)
6His, N-terminus
(1)
GST, N-terminus
(4)
His
(7)
His-GST
(2)
His-GST, N-terminus
(1)
Human IgG1 Fc, N-terminus
(1)
Myc-DDK (Flag)
(4)
Species
Bovine
(1)
Human
(15)
Mouse
(5)
Rat
(2)
Source
293T Cells
(1)
E. coli
(14)
HEK 293 Cells
(5)
Human Cells
(1)
Mammalian Cells
(1)
Wheat Germ Extract
(1)
Yeast
(1)
Purification
Purified
(5)
Low Endotoxin Level
Low endotoxin level
(8)
Biologically Active
Biologically active
(3)
E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261; 20 µg/$298; 100 µg/$454; 500 µg/$1,177
E. coli
His-GST, N-terminus
69kDa
10 µg/$283; 50 µg/$452; 200 µg/$902; 1 mg/$2,016; 5 mg/$3,151; 2 mg/$2,204
E. coli
His
16.5 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
His
16.2 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
E. coli
His-GST
66.9 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
HEK 293 Cells
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
The 343 amino acid recombinant protein with an N-terminal His tag has a predicted molecular mass of approximately 37.9 kD. The DTT-reduced and non-reduced protein migrate approximately above 60 kD by SDS-PAGE. The predicted N-terminal amino acid is His.
100 µg/$582
E. coli
His
Biologically active
50 µg/$411; 250 µg/$985; 10 µg/$276
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.9kD
10 µg/$277; 50 µg/$395; 500 µg/$1,262; 1 mg/$1,627
E. coli
GST, N-terminus
Less than 0.1 ng/mL (Less than 1 EU/µg) (determined by LAL method).
10 µg/$269; 50 µg/$372; 500 µg/$1,245; 1 mg/$1,627
HEK 293 Cells
Myc-DDK (Flag)
35.7 kDa
100 µg/$494
E. coli
GST, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
62.8 kDa
10 µg/$358; 50 µg/$458
E. coli
GST, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
62.2 kDa
10 µg/$301; 50 µg/$478
E. coli
His-GST
69.51 kDa
10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029
293T Cells
Myc-DDK (Flag)
35.7 kDa
20 µg/$150
Yeast
6His, N-terminus
100 µg/$446; 20 µg/$336; 1 mg/$1,460
HEK 293 Cells
Myc-DDK (Flag)
35.7 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
39.3 kDa
20 µg/$1,107
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.9 kDa
10 µg/$277; 50 µg/$389
HEK 293 Cells
Human IgG1 Fc, N-terminus
Biologically active
Less than 5.0 EU/mg protein (determined by LAL method).
~70 kDa (SDS-PAGE)
50 µg/$442
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
62.2kD
50 µg/$367; 500 µg/$1,609; 1 mg/$2,316; 10 µg/$264
E. coli
His
16.3 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
E. coli
His
16.6 kDa
10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107
E. coli
His
16.2 kDa
10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107
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