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LGALS3 / Galectin 3

lectin, galactoside-binding, soluble, 3

LGALS3 / Galectin 3 is a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.

Gene Name: lectin, galactoside-binding, soluble, 3
Synonyms: LGALS3, 35 kd lectin, 35 kDa lectin, CBP35, GAL3, Galactoside-binding protein, GALIG, IgE-binding protein, Laminin-binding protein, Gal-3, GALBP, MAC-2, Mac-2 antigen, L31, MAC2, CBP 35, Galactose-specific lectin 3, Galectin-3, L-31, Lectin L-29
Target Sequences: NM_002306 NP_002297.2 P17931

Publications (8)

1
Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes. Berger A, Mnk C, Schweizer M, Cichutek K, Schle S, Flory E. The Journal of biological chemistry. 2010 285:12248-54. [PubMed:20178977] [PMC:PMC2852964]
2
AlphaB-crystallin is found in detergent-resistant membrane microdomains and is secreted via exosomes from human retinal pigment epithelial cells. Gangalum RK, Atanasov IC, Zhou ZH, Bhat SP. The Journal of biological chemistry. 2011 286:3261-9. [PubMed:21097504] [PMC:PMC3030331]
3
FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. Kuang SQ, Medina-Martinez O, Guo DC, Gong L, Regalado ES, Reynolds CL, Boileau C, Jondeau G, Prakash SK, Kwartler CS, Zhu LY, Peters AM, Duan XY, Bamshad MJ, Shendure J, Nickerson DA, Santos-Cortez RL, Dong X, Leal SM, Majesky MW, Swindell EC, Jamrich M, Milewicz DM. The Journal of clinical investigation. 2016 126:948-61. (WB; Mouse) [Full Text Article] [PubMed:26854927] [PMC:PMC4767350]
4
Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners. Gallardo-Vara E, Ruiz-Llorente L, Casado-Vela J, Ruiz-Rodríguez MJ, López-Andrés N, Pattnaik AK, Quintanilla M, Bernabeu C. Cells. 2019 September;8:E1082. [Full Text Article] [PubMed:31540324] [PMC:PMC6769930]
5
Blockade of N-Glycosylation Promotes Antitumor Immune Response of T Cells. Shigemi Sasawatari, Yuki Okamoto, Atsushi Kumanogoh, Toshihiko Toyofuku. Journal of immunology (Baltimore, Md. : 1950). 2020 March;204:1373-1385. [Full Text Article] [PubMed:31969386] Related Antibodies: LS-C140105.
6
A Small Peptide Ac-SDKP Inhibits Radiation-Induced Cardiomyopathy. Umesh C Sharma, Swati D Sonkawade, Joseph A Spernyak, Sandra Sexton, Juliane Nguyen, Suraj Dahal, Kristopher M Attwood, Anurag K Singh, Jop H van Berlo, Saraswati Pokharel. Circulation. Heart failure. 2018 August;11:e004867. [Full Text Article] [PubMed:30354563] [PMC:PMC6205206]
7
Improvement in insulin sensitivity and prevention of high fat diet-induced liver pathology using a CXCR2 antagonist. Brett E Phillips, Louise Lantier, Carl Engman, Yesica Garciafigueroa, Aatur Singhi, Massimo Trucco, Christos Mantzoros, David Wasserman, Nick Giannoukakis. Cardiovascular Diabetology. 2022 July;21:130. [Full Text Article] [PubMed:35831885] [PMC:PMC9277870]
8
Combination Treatment with the Vimentin-Targeting Antibody hzVSF and Tenofovir Suppresses Woodchuck Hepatitis Virus Infection in Woodchucks. Kyle E Korolowicz, Manasa Suresh, Bin Li, Xu Huang, Changsuek Yon, Bhaskar V Kallakury, Kyoung-Pil Lee, Sungman Park, Yoon-Won Kim, Stephan Menne. Cells. 2021 September;10:2321. [Full Text Article] [PubMed:34571970] [PMC:PMC8466705]
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ELISA Kits (39)
Cell-Based (1)
Competitive EIA (3)
Custom (3)
Sandwich (28)
Sandwich CLIA (4)
LGALS3 / Galectin 3 (39)
Human (14)
Mouse (11)
Rat (9)
Dog (1)
Guinea pig (1)
Monkey (1)
Pig (1)
Porcine (1)
Rabbit (1)
Sheep (1)
12 x 8-Well Microstrips (4)
96-Well Microplate (10)
96-Well Strip Plate (25)
No (38)
Yes (1)
Adherent Cell Cultures (1)
Cell Culture Supernatants (12)
Cell Lysates (6)
Plasma (31)
Saliva (1)
Serum (31)
Tissue Homogenates (12)
LGALS3 / Galectin 3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
LGALS3 / Galectin 3 ELISA Kit
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Sandwich
96-Well Microplate
Rat
3.28 - 800 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$588
LGALS3 / Galectin 3 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$818
LGALS3 / Galectin 3 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
8.19 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$700
LGALS3 / Galectin 3 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.819 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$588
LGALS3 / Galectin 3 ELISA Kit
Select
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
LGALS3 / Galectin 3 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
LGALS3 / Galectin 3 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
LGALS3 / Galectin 3 ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
LGALS3 / Galectin 3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
LGALS3 / Galectin 3 ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Human
63 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$618
LGALS3 / Galectin 3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
LGALS3 / Galectin 3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
LGALS3 / Galectin 3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$760
LGALS3 / Galectin 3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
LGALS3 / Galectin 3 ELISA Kit
Select
Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$929
LGALS3 / Galectin 3 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
LGALS3 / Galectin 3 ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$685
LGALS3 / Galectin 3 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$685
LGALS3 / Galectin 3 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
LGALS3 / Galectin 3 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
LGALS3 / Galectin 3 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
LGALS3 / Galectin 3 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
15 - 1000 pg/ml
Chemiluminescent
Cell Lysates, Plasma, Serum
1 Plate/$649
LGALS3 / Galectin 3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$669
LGALS3 / Galectin 3 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).