LFNG / Lunatic Fringe

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

LFNG / Lunatic Fringe is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene.

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Products

Proteins (8)

Type

Over-Expression Lysate (6)

Recombinant (2)

Target

LFNG / Lunatic Fringe (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (6)

Species

Human (5)

Source

293T Cells (3)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human LFNG / Lunatic Fringe Protein (Recombinant GST, N-terminus) (aa1-250) - LS-G56853

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human LFNG / Lunatic Fringe Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81971

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.7 kDa

Price:

20 µg/$150

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Human LFNG / Lunatic Fringe Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81969

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.77 kDa

Price:

20 µg/$150

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Human LFNG / Lunatic Fringe Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81970

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.59 kDa

Price:

20 µg/$150

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Human LFNG / Lunatic Fringe Protein (Recombinant GST) (Full Length) - LS-G29190

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

53.24 kDa

Price:

10 µg/$479; 25 µg/$670

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LFNG / Lunatic Fringe Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G129598

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.7 kDa

Price:

100 µg/$494

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LFNG / Lunatic Fringe Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120273

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.77 kDa

Price:

100 µg/$494

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LFNG / Lunatic Fringe Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120274

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.59 kDa

Price:

100 µg/$494

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