LF / LTF / Lactoferrin

lactotransferrin

Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate.Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity, which depends on the extracellular cation concentration. Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. Can also prevent bacterial biofilm development in P.aeruginosa infection. Has weak antifungal activity against C.albicans. Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. Promotes binding of species C adenoviruses to epithelial cells, promoting adenovirus infection. Can inhibit papillomavirus infections. Stimulates the TLR4 signaling pathway leading to NF-kappa-B activation and subsequent pro-inflammatory cytokine production while also interfering with the lipopolysaccharide (LPS)-stimulated TLR4 signaling. Inhibits neutrophil granulocyte migration to sites of apoptosis, when secreted by apoptotic cells. Stimulates VEGFA-mediated endothelial cell migration and proliferation. Binds heparin, chondroitin sulfate and possibly other glycosaminoglycans (GAGs). Also binds specifically to pneumococcal surface protein A (pspA), the lipid A portion of bacterial lipopolysaccharide (LPS), lysozyme and DNA.Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site.Kaliocin-1 has antimicrobial activity and is able to permeabilize different ions through liposomal membranes.Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.Isoform DeltaLf: transcription factor with antiproliferative properties and ability to induce cell cycle arrest. Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.

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Proteins (23)

Type

Native (2)

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Recombinant (17)

Target

LF / LTF / Lactoferrin (23)

Publications

No (23)

Tag

6His, C-terminus (2)

GST (1)

His (6)

His, C-Terminal (1)

His, N-Terminal (2)

His-GST (4)

His-S (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Bovine (2)

Dog (1)

Goat (1)

Human (10)

Mouse (4)

Pig (1)

Rat (2)

Source

293T Cells (1)

E. coli (12)

HEK 293 Cells (5)

Human (1)

Human Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (4)

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Dog LF / LTF / Lactoferrin Protein (Recombinant His-S) (aa28-351) - LS-G12792

Source:

E. coli

Tag:

His-S

Molecular Weight:

41.1 kDa

Price:

10 µg/$243; 50 µg/$291; 100 µg/$339; 200 µg/$402; 1 mg/$1,156; 500 µg/$802; 5 mg/$1,982; 2 mg/$1,298

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Bovine LF / LTF / Lactoferrin Protein (Recombinant His-T7) (aa25-352) - LS-G12791

Source:

E. coli

Tag:

His-T7

Molecular Weight:

40.3 kDa

Price:

10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723

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Human LF / LTF / Lactoferrin Protein (Recombinant 6His, C-terminus) (Gly20-Lys710) - LS-G51833

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

77.3kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Mouse LF / LTF / Lactoferrin Protein (Recombinant His-GST) (aa406-549) - LS-G12798

Source:

E. coli

Tag:

His-GST

Molecular Weight:

47.4 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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Human LF / LTF / Lactoferrin Protein (Over-Expression Lysate His, N-Terminal) (Gly20-Lys711) - LS-G136081

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~76 kDa

Price:

100 µg/$298

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Human LF / LTF / Lactoferrin Protein (Over-Expression Cell Culture Supernatant His, N-Terminal) (Gly20-Lys711) - LS-G136083

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~76 kDa

Price:

200 µl/$283

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LF / LTF / Lactoferrin Protein (Native) (Full Length) - LS-G132072

Source:

Human

Tag:

None

Price:

1 mg/$556; 10 mg/$3,607

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Goat LF / LTF / Lactoferrin Protein (Recombinant His) (aa25-352) - LS-G12797

Source:

E. coli

Tag:

His

Molecular Weight:

37.9 kDa

Price:

10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029

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Mouse LF / LTF / Lactoferrin Protein (Recombinant His-GST) (aa550-707) - LS-G12801

Source:

E. coli

Tag:

His-GST

Molecular Weight:

49.7 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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LF / LTF / Lactoferrin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118042

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

78.37 kDa

Price:

100 µg/$494

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Human LF / LTF / Lactoferrin Protein (Recombinant GST) (Full Length) - LS-G29224

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

104.7 kDa

Price:

2 µg/$439

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Human LF / LTF / Lactoferrin Protein (Native) - LS-G37777

Tag:

None

Price:

5 mg/$352

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Human LF / LTF / Lactoferrin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66156

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.1 kDa

Price:

20 µg/$1,107

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Human LF / LTF / Lactoferrin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77059

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

78.37 kDa

Price:

20 µg/$150

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Mouse LF / LTF / Lactoferrin Protein (Recombinant His, C-Terminal) (Met1-Gln707) - LS-G98811

Source:

HEK 293 Cells

Tag:

His, C-Terminal

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

77.2 kDa

Price:

50 µg/$721

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Bovine LF / LTF / Lactoferrin Protein (Recombinant His) (aa40-243) - LS-G141170

Source:

E. coli

Sequence Length:

203 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

22.44 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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Human LF / LTF / Lactoferrin Protein (Recombinant 6His, C-terminus) (Gly20-Lys710) - LS-G139626

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

77.3 kDa

Price:

10 µg/$288; 50 µg/$436

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Human LF / LTF / Lactoferrin Protein (Recombinant His) (aa337-449) - LS-G12793

Source:

E. coli

Tag:

His

Molecular Weight:

13.7 kDa

Price:

10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646

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Human LF / LTF / Lactoferrin Protein (Recombinant His) (aa542-685) - LS-G12794

Source:

E. coli

Tag:

His

Molecular Weight:

17.8 kDa

Price:

10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329

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Mouse LF / LTF / Lactoferrin Protein (Recombinant His-GST) (aa63-193) - LS-G12796

Source:

E. coli

Tag:

His-GST

Molecular Weight:

46.2 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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Pig LF / LTF / Lactoferrin Protein (Recombinant His-GST) (aa25-348) - LS-G12799

Source:

E. coli

Tag:

His-GST

Molecular Weight:

68.0 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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Rat LF / LTF / Lactoferrin Protein (Recombinant His) (aa550-668) - LS-G12802

Source:

E. coli

Tag:

His

Molecular Weight:

15.0 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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Rat LF / LTF / Lactoferrin Protein (Recombinant His) (aa64-193) - LS-G12805

Source:

E. coli

Tag:

His

Molecular Weight:

16.0 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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