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Leptin

Leptin is a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.

Gene Name: Leptin
Synonyms: LEP, Leptin, LEPD, Obese protein, Obese, mouse, homolog of, Obesity factor, OBS, OB
Target Sequences: NM_000230 NP_000221.1 P41159

Publications (5)

1
Leptin as a potential target for estrogen receptor-positive breast cancer. Yom CK, Lee KM, Han W, Kim SW, Kim HS, Moon BI, Jeong KY, Im SA, Noh DY. Journal of breast cancer. 2013 16:138-45. (WB; Human) [Full Text Article] [PubMed:23843844] [PMC:PMC3706857] Related Antibodies: LS-C25172.
2
Hypoplastic left heart syndrome is associated with structural and vascular placental abnormalities and leptin dysregulation. Jones HN, Olbrych SK, Smith KL, Cnota JF, Habli M, Ramos-Gonzales O, Owens KJ, Hinton AC, Polzin WJ, Muglia LJ, Hinton RB. Placenta. 2015 36:1078-86. (WB; Mouse) [Full Text Article] [PubMed:26278057] Related Antibodies: LS-B1459.
3
Delta-like protein 1 in the pituitary-adipose axis in the adult male mouse. Bello AR, Puertas-Avendaño RA, González-Gómez MJ, González-Gómez M, Laborda J, Damas C, Ruiz-Hidalgo M, Diaz C. Journal of neuroendocrinology. 2017 August;29: [Full Text Article] [PubMed:28718206] [PMC:PMC6084355]
4
Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance. Kirthana Ganeshan, Joni Nikkanen, Kevin Man, Yew Ann Leong, Yoshitaka Sogawa, J Alan Maschek, Tyler Van Ry, D Nyasha Chagwedera, James E Cox, Ajay Chawla. Cell. 2019 April;177:399-413.e12. [Full Text Article] [PubMed:30853215] [PMC:PMC6456449]
5
Effects of 3-nitrooxypropanol on rumen fermentation, lactational performance, and resumption of ovarian cyclicity in dairy cows. A Melgar, M T Harper, J Oh, F Giallongo, M E Young, T L Ott, S Duval, A N Hristov. Journal of dairy science. 2020 Jan;103:410-432. [Full Text Article] [PubMed:31733848]
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Products
Proteins (35)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Recombinant (30)
Leptin (35)
No (35)
8His, N-terminus (1)
GST (1)
His (4)
His, N-Terminal (3)
His, N-terminus (1)
His,N-terminus (1)
His-GST, N-terminus (1)
His-S (1)
His-S, N-terminus (1)
His-T7 (2)
Myc-DDK (Flag) (3)
Bovine (2)
Chicken (1)
Goldfish (1)
Horse (1)
Human (21)
Mouse (5)
Rat (3)
293T Cells (1)
E. coli (27)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Yeast (1)
Purified (12)
Low endotoxin level (15)
Biologically active (10)
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
16.0 kDa
200 µg/$268; 1 mg/$349
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
16.2 kDa
200 µg/$268; 1 mg/$349
Leptin Protein - Recombinant Leptin By SDS-PAGE
Select
E. coli
His, N-terminus
18.4 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
Select
E. coli
His-S
21.7 kDa
10 µg/$246; 50 µg/$299; 100 µg/$352; 200 µg/$442; 1 mg/$1,242; 500 µg/$882; 5 mg/$2,097; 2 mg/$1,391
Select
E. coli
8His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
18.3kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
Leptin Protein - Purified recombinant protein LEP was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
16 kDa
20 µg/$1,107
Leptin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
18.64 kDa
20 µg/$150
Select
E. coli
His
19.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Leptin Protein - 12.5% SDS-PAGE of human LEP stained with Coomassie Blue
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Wheat Germ Extract
GST
41.8 kDa
10 µg/$479; 25 µg/$670
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
16.3 kDa (SDS-PAGE)
5 mg/$432; 200 µg/$253; 1 mg/$286
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
16.1kD
10 µg/$229; 50 µg/$248; 500 µg/$313; 1 mg/$358
Select
None
Biologically active
16.0 kD
1 mg/$476
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
16.1 kDa
10 µg/$229; 50 µg/$248
Select
Yeast
His,N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
18.3 kDa
10 µg/$288; 50 µg/$436
Select
E. coli
None
Biologically active
16.0 kDa
200 µg/$279; 1 mg/$365
Select
E. coli
None
Biologically active
16.2 kDa
200 µg/$279; 1 mg/$365
Leptin Protein - Recombinant Leptin (LEP) by SDS-PAGE
Select
E. coli
His-S, N-terminus
22.6kDa
10 µg/$259; 50 µg/$331; 200 µg/$602; 100 µg/$482; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
Select
E. coli
None
Less than 0.1 ng/µg protein.
16.2 kDa
1000 µg/$427; 5000 µg/$836; 200 µg/$741
Leptin Protein - Active Leptin (LEP) by WB
Select
E. coli
His-GST, N-terminus
46kDa
10 µg/$259; 50 µg/$331; 200 µg/$602; 100 µg/$482; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
Leptin Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
E. coli
His, N-Terminal
14 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 200 µg/$484
Select
HEK 293 Cells
His, N-Terminal
~16 kDa
100 µg/$298
Select
HEK 293 Cells
His, N-Terminal
~16 kDa
200 µl/$283
Select
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
16.0 kDa
1 mg/$355; 200 µg/$278; 5 mg/$670
Leptin Protein - Recombinant Mouse Leptin
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
16.1 kDa
10 µg/$225; 50 µg/$253
Select
E. coli
145 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
16.06 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
Viewing 1-25 of 35 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).