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LEF1

lymphoid enhancer-binding factor 1

Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.

Gene Name: lymphoid enhancer-binding factor 1
Synonyms: LEF1, LEF-1, TCF7L3, TCF1-alpha, TCF10, TCF1ALPHA
Target Sequences: NM_016269 NP_057353.1 Q9UJU2

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Products
Proteins (12)
Over-Expression Lysate (8)
Recombinant (4)
LEF1 (12)
No (12)
GST (1)
GST, N-terminus (4)
His, N-Terminal (1)
Myc-DDK (Flag) (6)
Human (7)
293T Cells (3)
E. coli (3)
HEK 293 Cells (3)
Wheat Germ Extract (3)
Purified (1)
LEF1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
44 kDa
20 µg/$130
LEF1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
41 kDa
20 µg/$130
LEF1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
42.5 kDa
20 µg/$130
LEF1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
44 kDa
100 µg/$458
LEF1 Protein
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E. coli
His, N-Terminal
44 kDa
50 µg/$390
LEF1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
41 kDa
100 µg/$458
LEF1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
42.5 kDa
100 µg/$458
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E. coli
GST, N-terminus
42 kDa
200 µg/$348
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E. coli
GST, N-terminus
39 kDa
200 µg/$348
LEF1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$461; 25 µg/$611
LEF1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$461; 25 µg/$611
LEF1 Protein - 12.5% SDS-PAGE of human LEF1 stained with Coomassie Blue
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Wheat Germ Extract
GST
69.63 kDa
10 µg/$461; 25 µg/$611
Viewing 1-12 of 12 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).