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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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LECT1 / Chondromodulin-I

leukocyte cell derived chemotaxin 1

LECT1 / Chondromodulin-I is a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: leukocyte cell derived chemotaxin 1
Synonyms: LECT1, BRICHOS domain containing 3, CHM-I, CHMI, Chondromodulin I, Chondromodulin-I, Chondromodulin-1, MYETS1, BRICD3, CHM1, Chondromodulin
Target Sequences: NM_007015 NP_008946.1 O75829

Publications (1)

1
TGF-ß mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease. Munjal C, Opoka AM, Osinska H, James JF, Bressan GM, Hinton RB. Disease models & mechanisms. 2014 7:987-96. (IHC; Mouse) [Full Text Article] [PubMed:25056700] [PMC:PMC4107327] Related Antibodies: LS-C80668.

Viewing 1-14 of 14 items
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HEK 293 Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
20µg   $265.00; 100µg   $425.00
Select
E. coli
GST,N-terminus
38 kDa
200µg   $315.00
Select
HEK 293 Cells
Human IgG1 Fc,N-terminus
WB
The 379 amino acid recombinant protein has a predicted molecular mass of 42.1 kDa.
300µg   $305.00
LECT1 / Chondromodulin-I Protein
Select
E. coli
His
100µg   1mg/ml   $365.00; 0.5mg   1mg/ml   $935.00
Select
E. coli
His
16.2 kDa
5µg   $195.00; 20µg   $255.00; 1mg   $3,780.00
LECT1 / Chondromodulin-I Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
36.97 kDa
20µg   $195.00
LECT1 / Chondromodulin-I Protein - Recombinant Leukocyte Cell Derived Chemotaxin 1 By SDS-PAGE
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E. coli
His + T7
26.8 kDa
10µg   $285.00; 50µg   $465.00; 100µg   $635.00; 200µg   $920.00; 1mg   $2,370.00
LECT1 / Chondromodulin-I Protein - 12.5% SDS-PAGE of human LECT1 stained with Coomassie Blue
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Wheat Germ Extract
GST
63.5 kDa
10µg   $425.00; 25µg   $590.00; 2µg   $385.00
LECT1 / Chondromodulin-I Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc + DDK
36.97 kDa
100µg   $375.00
LECT1 / Chondromodulin-I Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His + SUMO,N-terminus
1mg   $1,290.00; 500µg   $830.00; 200µg   $485.00; 100µg   $355.00; 50µg   $275.00; 10µg   $245.00
Select
E. coli
His
16.3 kDa
5µg   $195.00; 20µg   $255.00; 1mg   $2,850.00
LECT1 / Chondromodulin-I Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
E. coli
6His,N-terminus
16.1 kDa
10µg   $215.00; 50µg   $275.00; 100µg   $325.00; 200µg   $465.00
LECT1 / Chondromodulin-I Protein
Select
E. coli
His
100µg   1mg/ml   $315.00; 0.5mg   1mg/ml   $695.00
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
42.1 kDa
20µg   $335.00; 100µg   $680.00

Viewing 1-14 of 14 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).