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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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LECT1 / Chondromodulin-I

leukocyte cell derived chemotaxin 1

LECT1 / Chondromodulin-I is a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: leukocyte cell derived chemotaxin 1
Synonyms: LECT1, BRICHOS domain containing 3, CHM-I, CHMI, Chondromodulin I, Chondromodulin-I, Chondromodulin-1, MYETS1, BRICD3, CHM1, Chondromodulin
Target Sequences: NM_007015 NP_008946.1 O75829

Publications (1)

1
TGF-ß mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease. Munjal C, Opoka AM, Osinska H, James JF, Bressan GM, Hinton RB. Disease models & mechanisms. 2014 7:987-96. (IHC; Mouse) [Full Text Article] [PubMed:25056700] [PMC:PMC4107327] Related Antibodies: LS-C80668.

Filtered by: None
Type
Over-Expression Lysate (4)
Recombinant (9)
Target
LECT1 / Chondromodulin-I (13)
Tag
6His + SUMO,N-terminus (1)
6His,N-terminus (1)
Fc (1)
GST (1)
GST,N-terminus (1)
His (4)
His + T7 (1)
Myc + DDK (3)
Species
Human (10)
Source
293T Cells (1)
E. coli (8)
HEK 293 Cells (2)
Human Cells (1)
Wheat Germ Extract (1)
Purification
Purified (9)
Low Endotoxin Level
Low endotoxin level (1)
Showing 1-13 of 13 results

LECT1 / Chondromodulin-I Protein (Over-Expression Lysate GST,N-terminus) - LS-G42296
E. coli
GST,N-terminus
38 kDa
200µg  $315.00

Human LECT1 / Chondromodulin-I Protein (Recombinant GST) (Full Length) - LS-G32480
Wheat Germ Extract
GST
63.5 kDa
10µg  $415.00; 25µg  $590.00
12.5% SDS-PAGE of human LECT1 stained with Coomassie Blue

Human LECT1 / Chondromodulin-I Protein (Recombinant His) - LS-G19526
E. coli
His
16.3 kDa
5µg  $195.00; 20µg  $255.00; 1mg  $2,850.00

Human LECT1 / Chondromodulin-I Protein (Recombinant 6His,N-terminus) (Glu215-Val334) - LS-G26562
E. coli
6His,N-terminus
16.1 kDa
10µg  $215.00; 50µg  $275.00; 100µg  $325.00; 200µg  $465.00

Human LECT1 / Chondromodulin-I Protein (Recombinant 6His + SUMO,N-terminus) (aa215-334) - LS-G56374
E. coli
6His + SUMO,N-terminus
1mg  $1,245.00; 500µg  $785.00; 200µg  $475.00; 100µg  $355.00; 50µg  $275.00; 10µg  $235.00
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Human LECT1 / Chondromodulin-I Protein (Recombinant His) - LS-G2737
E. coli
His
100µg 1mg/ml  $315.00; 0.5mg 1mg/ml  $695.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

Human LECT1 / Chondromodulin-I Protein (Recombinant His) - LS-G19532
E. coli
His
16.2 kDa
5µg  $195.00; 20µg  $255.00; 1mg  $3,780.00

Human LECT1 / Chondromodulin-I Protein (Recombinant His) - LS-G2751
E. coli
His
100µg 1mg/ml  $365.00; 0.5mg 1mg/ml  $935.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

LECT1 / Chondromodulin-I Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G114917
HEK 293 Cells
Myc + DDK
36.97 kDa
100µg  $345.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

LECT1 / Chondromodulin-I Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G121802
HEK 293 Cells
Myc + DDK
36.97 kDa
100µg  $345.00

Human LECT1 / Chondromodulin-I Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G87245
293T Cells
Myc + DDK
36.97 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human LECT1 / Chondromodulin-I Protein (Recombinant His + T7) (aa134-334) - LS-G14978
E. coli
His + T7
26.8 kDa
10µg  $285.00; 50µg  $465.00; 100µg  $635.00; 200µg  $920.00; 1mg  $2,370.00
Recombinant Leukocyte Cell Derived Chemotaxin 1 By SDS-PAGE

Human LECT1 / Chondromodulin-I Protein (Recombinant Fc) (Glu215-Val333) - LS-G97653
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
42.1 kDa
20µg  $335.00; 100µg  $680.00
Showing 1-13 of 13 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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