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LECT1 / Chondromodulin-I

leukocyte cell derived chemotaxin 1

LECT1 / Chondromodulin-I is a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: leukocyte cell derived chemotaxin 1
Synonyms: LECT1, BRICHOS domain containing 3, CHM-I, CHMI, Chondromodulin I, Chondromodulin-I, Chondromodulin-1, MYETS1, BRICD3, CHM1, Chondromodulin
Target Sequences: NM_007015 NP_008946.1 O75829

Publications (1)

1
TGF-ß mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease. Munjal C, Opoka AM, Osinska H, James JF, Bressan GM, Hinton RB. Disease models & mechanisms. 2014 7:987-96. (IHC; Mouse) [Full Text Article] [PubMed:25056700] [PMC:PMC4107327] Related Antibodies: LS-C80668.

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Products
Antibodies (28)
Primary (28)
LECT1 / Chondromodulin-I (28)
Human (28)
Mouse (13)
Rat (4)
Bovine (3)
Monkey (3)
IHC (3)
IHC-P (3)
WB (23)
ELISA (6)
ICC (1)
IF (2)
IP (1)
rabbit (28)
Product Group
IHCPlus (1)
IgG (17)
polyclonal pc (28)
APC (1)
APC Conjugated (2)
Biotin Conjugated (4)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (10)
aa134-334 (8)
aa110-159 (4)
aa253-281 (1)
No (27)
Yes (1)
LECT1 / Chondromodulin-I Antibody - Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with LECT1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (aa253-281) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
LECT1 / Chondromodulin-I Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (aa134-334) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
LECT1 / Chondromodulin-I Antibody
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LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321
LECT1 / Chondromodulin-I Antibody - Immunohistochemistry of paraffin-embedded human heart tissue at dilution 1:100
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LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
Select
LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Select
LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
Select
LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal Antibody
Human
IP, WB
Unconjugated
100 µl/$749
Select
LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
Select
LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
Select
LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
Select
LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$937
Select
LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$937
Select
LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$937
Select
LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$937
Select
LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (PE) Antibody
Human
WB
PE Conjugated
100 µl/$937
LECT1 / Chondromodulin-I Antibody - 721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 10-20%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (aa110-159) (HRP) Antibody
Mouse, Bovine, Rat, Human, Monkey
WB
HRP Conjugated
100 µl/$469
LECT1 / Chondromodulin-I Antibody - 721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 10-20%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (aa110-159) (Biotin) Antibody
Mouse, Bovine, Rat, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
LECT1 / Chondromodulin-I Antibody - 721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 10-20%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (aa110-159) (FITC) Antibody
Mouse, Bovine, Rat, Human, Monkey
WB
FITC Conjugated
100 µl/$469
LECT1 / Chondromodulin-I Antibody - Western blot of recombinant LECT1 / Chondromodulin-I.
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LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (aa134-334) (HRP) Antibody
Mouse, Human
WB
HRP Conjugated
100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593
LECT1 / Chondromodulin-I Antibody - Western blot of recombinant LECT1 / Chondromodulin-I.
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LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (aa134-334) (FITC) Antibody
Mouse, Human
WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716
LECT1 / Chondromodulin-I Antibody - Western blot of recombinant LECT1 / Chondromodulin-I.
Select
LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (aa134-334) (APC) Antibody
Mouse, Human
WB
APC Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
LECT1 / Chondromodulin-I Antibody - Western blot of recombinant LECT1 / Chondromodulin-I.
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LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (aa134-334) (PE) Antibody
Mouse, Human
WB
PE Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
LECT1 / Chondromodulin-I Antibody - Western blot of recombinant LECT1 / Chondromodulin-I.
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LECT1 / Chondromodulin-I Rabbit anti-Human Polyclonal (aa134-334) (APC, Cy7) Antibody
Mouse, Human
WB
APC, Cy7 Conjugated
100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).