LDOC1 contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.
|Gene Name:||leucine zipper, down-regulated in cancer 1|
|Synonyms:||LDOC1, Breast cancer, up-regulated 1, Mart7, BCUR1, Mar7, Protein LDOC1|
|Target Sequences:||NM_012317 NP_036449.1 O95751|
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