LDLRAD4 / C18orf1

low density lipoprotein receptor class A domain containing 4

Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.

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Products

Proteins (7)

Type

Over-Expression Lysate (6)

Recombinant (1)

Target

LDLRAD4 / C18orf1 (7)

Publications

No (7)

Tag

Myc-DDK (Flag) (7)

Species

Human (4)

Source

293T Cells (3)

HEK 293 Cells (4)

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Human LDLRAD4 / C18orf1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67561

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25.6 kDa

Price:

20 µg/$1,107

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Human LDLRAD4 / C18orf1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80151

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.6 kDa

Price:

20 µg/$150

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Human LDLRAD4 / C18orf1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80152

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.9 kDa

Price:

20 µg/$150

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Human LDLRAD4 / C18orf1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80154

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25.6 kDa

Price:

20 µg/$150

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LDLRAD4 / C18orf1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104529

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25.6 kDa

Price:

100 µg/$494

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LDLRAD4 / C18orf1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122574

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.9 kDa

Price:

100 µg/$494

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LDLRAD4 / C18orf1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116712

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.6 kDa

Price:

100 µg/$494

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