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LDHB / Lactate Dehydrogenase B

lactate dehydrogenase B

LDHB / Lactate Dehydrogenase B encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene Name: lactate dehydrogenase B
Synonyms: LDHB, LDH heart subunit, Lactate dehydrogenase H chain, Lactate dehydrogenase B, LDH-B, TRG-5, LDH-H, LDHBD
Target Sequences: NM_002300 NP_002291.1 P07195

Publications (3)

1
M-LDH serves as a sarcolemmal K(ATP) channel subunit essential for cell protection against ischemia. Crawford RM, Budas GR, Jovanovi S, Ranki HJ, Wilson TJ, Davies AM, Jovanovi A. The EMBO journal. 2002 21:3936-48. [PubMed:12145195] [PMC:PMC126135]
2
Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis. Koukourakis MI, Giatromanolaki A, Sivridis E, Bougioukas G, Didilis V, Gatter KC, Harris AL. British journal of cancer. 2003 89:877-85. [PubMed:12942121] [PMC:PMC2394471]
3
Small and big Hodgkin-Reed-Sternberg cells of Hodgkin lymphoma cell lines L-428 and L-1236 lack consistent differences in gene expression profiles and are capable to reconstitute each other. Rengstl B, Kim S, Döring C, Weiser C, Bein J, Bankov K, Herling M, Newrzela S, Hansmann ML, Hartmann S. PloS one. 2017 12:e0177378. (ICC, WB, ELISA; Human) [Full Text Article] [PubMed:28505189] Related Antibodies: LS-B4366.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).