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LDHA / LDH1

Lactate Dehydrogenase A

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene.

Gene Name: Lactate Dehydrogenase A
Synonyms: LDHA, LDH muscle subunit, LDH1, Lactate dehydrogenase M, LDH-M, GSD11, Lactate dehydrogenase A, LDH-A, LDHM, PIG19, Proliferation-inducing gene 19
Target Sequences: NM_005566 NP_005557.1 P00338

Publications (2)

1
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL, Dang CV. Proceedings of the National Academy of Sciences of the United States of America. 2010 107:2037-42. (WB) [PubMed:20133848] [PMC:PMC2836706]
2
Postpartum supplementation with fermented ammoniated condensed whey altered nutrient partitioning to support hepatic metabolism. R Caputo Oliveira, S J Erb, R S Pralle, H T Holdorf, C R Seely, H M White. The Breast : official journal of the European Society of Mastology. 2020 Aug;;103:7055-7067. [Full Text Article] [PubMed:32534927] Related Antibodies: LS-C143436.

☰ Filters
Products
Proteins (20)
Over-Expression Lysate (6)
Recombinant (14)
LDHA / LDH1 (20)
No (20)
6His, C-terminus (2)
6His, N-terminus (2)
6His-SUMO, N-terminus (1)
GST (1)
His (4)
His-GST-S (1)
His-T7 (1)
Myc-DDK (Flag) (7)
Human (11)
Mouse (3)
Pig (1)
Rat (1)
Staphylococcus aureus (1)
293T Cells (3)
E. coli (10)
HEK 293 Cells (4)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (4)
Low endotoxin level (4)
Biologically active (1)
LDHA / LDH1 Protein - Purified recombinant protein LDHA was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
36.5 kDa
20 µg/$1,107
LDHA / LDH1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
LDHA / LDH1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
36.5 kDa
100 µg/$494
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
38.8 kDa
10 µg/$344; 50 µg/$584
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
37.5 kDa
10 µg/$344; 50 µg/$584
LDHA / LDH1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
39.7 kDa
100 µg/$494
LDHA / LDH1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
35.1 kDa
1 mg/$1,443; 100 µg/$503; 20 µg/$406
LDHA / LDH1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
30 kDa
100 µg/$494
LDHA / LDH1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
30 kDa
20 µg/$150
LDHA / LDH1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
36.5 kDa
20 µg/$150
LDHA / LDH1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
39.7 kDa
20 µg/$150
LDHA / LDH1 Protein
Select
E. coli
His
Biologically active
100 µg/$342; 500 µg/$641; 20 µg/$254
LDHA / LDH1 Protein - Recombinant Lactate Dehydrogenase A By SDS-PAGE
Select
E. coli
His-T7
40.8 kDa
10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796
LDHA / LDH1 Protein - Recombinant Lactate Dehydrogenase A By SDS-PAGE
Select
E. coli
His
38 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
LDHA / LDH1 Protein - Recombinant Lactate Dehydrogenase A By SDS-PAGE
Select
E. coli
His
38.0 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
LDHA / LDH1 Protein - Recombinant  Lactate Dehydrogenase A By SDS-PAGE
Select
E. coli
His-GST-S
66.6 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
LDHA / LDH1 Protein - 12.5% SDS-PAGE of human LDHA stained with Coomassie Blue
Select
Wheat Germ Extract
GST
63.1 kDa
10 µg/$479; 25 µg/$670
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
37.5kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
Select
E. coli
His
39.2 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
38.8kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).