LCN2 / Lipocalin 2 / NGAL

lipocalin 2

Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

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Products

Proteins (35)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Recombinant (31)

Target

LCN2 / Lipocalin 2 / NGAL (35)

Publications

No (35)

Tag

10His, C-terminus (1)

6His, C-terminus (6)

6His, N-terminus (3)

8His, N-terminus (1)

DDK (Flag) (1)

Fc, C-terminus (2)

GST (1)

His (8)

His, N-terminus (3)

His,C-terminus (1)

His,N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (3)

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Species

Dog (1)

Human (19)

Mouse (9)

Pig (1)

Rat (4)

Source

293T Cells (1)

Baculovirus (1)

E. coli (16)

HEK 293 Cells (9)

Human Cells (4)

Mammalian Cells (3)

Wheat Germ Extract (1)

Purification

Purified (12)

Low Endotoxin Level

Low endotoxin level (15)

Biologically Active

Biologically active (1)

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Dog LCN2 / Lipocalin 2 / NGAL Protein (Recombinant His) (aa23-198) - LS-G13755

Source:

E. coli

Tag:

His

Molecular Weight:

21.7 kDa

Price:

10 µg/$307; 50 µg/$602; 100 µg/$962; 200 µg/$1,156; 1 mg/$2,369; 500 µg/$1,876; 5 mg/$4,201; 2 mg/$2,562

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Human LCN2 / Lipocalin 2 / NGAL Protein (Recombinant) (aa21-198) - LS-G5592

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

41.0 kDa

Price:

10 µg/$388; 100 µg/$1,116; 500 µg/$2,095

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Human LCN2 / Lipocalin 2 / NGAL Protein (Recombinant 10His, C-terminus) - LS-G137715

Source:

HEK 293 Cells

Tag:

10His, C-terminus

Endotoxin Level:

Less than 0.01 ng/µg (determined by LAL method).

Molecular Weight:

The 193 amino acid recombinant protein has a predicted molecular mass of approximately 22 kD. The DTT-reduced and non-reduced protein migrate at approximately 24-28 and 23-26 kD by SDS-PAGE respectively. The N-terminal amino acid is blocked.

Price:

10 µg/$306; 25 µg/$375; 100 µg/$731; 500 µg/$1,895

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Human LCN2 / Lipocalin 2 / NGAL Protein (Recombinant His,N-terminus) - LS-G134288

Source:

E. coli

Tag:

His,N-terminus

Molecular Weight:

~25 kDa (SDS-PAGE)

Price:

10 µg/$274; 50 µg/$400

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Mouse LCN2 / Lipocalin 2 / NGAL Protein (Recombinant His,C-terminus) (Met1-Asn200) - LS-G138192

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

22.3 kDa

Price:

100 µg/$721

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LCN2 / Lipocalin 2 / NGAL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115888

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.4 kDa

Price:

100 µg/$494

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Mouse LCN2 / Lipocalin 2 / NGAL Protein (Recombinant His, N-terminus) - LS-G146235

Source:

E. coli

Tag:

His, N-terminus

Molecular Weight:

20.8kDa

Price:

20 µg/$270; 100 µg/$390

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Human LCN2 / Lipocalin 2 / NGAL Protein (Recombinant 6His, C-terminus) (Gln21-Gly198) - LS-G139125

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

21.8 kDa

Price:

10 µg/$368; 50 µg/$479

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Rat LCN2 / Lipocalin 2 / NGAL Protein (Recombinant His, N-terminus) - LS-G146357

Source:

E. coli

Tag:

His, N-terminus

Molecular Weight:

20.5kDa

Price:

20 µg/$270; 100 µg/$390

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Human LCN2 / Lipocalin 2 / NGAL Protein (Recombinant His, N-terminus) - LS-G145979

Source:

E. coli

Tag:

His, N-terminus

Molecular Weight:

20.5kDa

Price:

20 µg/$270; 100 µg/$390

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Pig LCN2 / Lipocalin 2 / NGAL Protein (Recombinant His-T7) (aa23-199) - LS-G24305

Source:

E. coli

Tag:

His-T7

Molecular Weight:

23.9 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Human LCN2 / Lipocalin 2 / NGAL Protein (Recombinant GST) (Full Length) - LS-G29181

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

47.41 kDa

Price:

10 µg/$479; 25 µg/$670

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Human LCN2 / Lipocalin 2 / NGAL Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Gln21-Gly198) - LS-G26847

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

22 kDa

Price:

200 µl/$283

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Human LCN2 / Lipocalin 2 / NGAL Protein (Over-Expression Lysate 8His, N-terminus) (Gln21-Gly198) - LS-G26705

Source:

HEK 293 Cells

Tag:

8His, N-terminus

Molecular Weight:

22 kDa

Price:

100 µg/$298

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Human LCN2 / Lipocalin 2 / NGAL Protein (Recombinant 6His, N-terminus) (Gln21-Gly198) - LS-G26974

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

22 kDa

Price:

10 µg/$289; 50 µg/$360; 100 µg/$432; 250 µg/$726

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Human LCN2 / Lipocalin 2 / NGAL Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66431

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.4 kDa

Price:

20 µg/$1,107

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Human LCN2 / Lipocalin 2 / NGAL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77696

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.4 kDa

Price:

20 µg/$150

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Human LCN2 / Lipocalin 2 / NGAL Protein (Recombinant His) (Met1-Gly198) - LS-G98618

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

22 kDa

Price:

100 µg/$721

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Rat LCN2 / Lipocalin 2 / NGAL Protein (Recombinant His) (Met1-Asn198) - LS-G98437

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

21.9 kDa

Price:

100 µg/$721

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Rat LCN2 / Lipocalin 2 / NGAL Protein (Recombinant DDK (Flag)) (aa1-198) - LS-G3804

Source:

HEK 293 Cells

Tag:

DDK (Flag)

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

~25kDa (SDS-PAGE)

Price:

10 µg/$323

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Mouse LCN2 / Lipocalin 2 / NGAL Protein (Recombinant His) - LS-G3311

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human LCN2 / Lipocalin 2 / NGAL Protein (Recombinant His) - LS-G1136

Source:

E. coli

Tag:

His

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Human LCN2 / Lipocalin 2 / NGAL Protein (Recombinant His) (aa21-198) - LS-G141163

Source:

E. coli

Sequence Length:

177 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

19.58 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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Mouse LCN2 / Lipocalin 2 / NGAL Protein (Recombinant 6His, C-terminus) (Gln21-Asn200) - LS-G138883

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

21.9 kDa

Price:

10 µg/$354; 50 µg/$429

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Mouse LCN2 / Lipocalin 2 / NGAL Protein (Recombinant Fc, C-terminus) (Gln21-Asn200) - LS-G138884

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

48 kDa

Price:

10 µg/$354; 50 µg/$429

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