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LCN2 / Lipocalin 2 / NGAL

lipocalin 2

Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

Gene Name: lipocalin 2
Synonyms: LCN2, 24p3, HNL, Lipocalin 2, Lipocalin-2, MSFI, Siderocalin LCN2, NGAL, p25, Lipocalin 2 (oncogene 24p3), Oncogene 24p3
Target Sequences: NM_005564 NP_005555.2 P80188

☰ Filters
Products
Proteins (37)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Recombinant (33)
LCN2 / Lipocalin 2 / NGAL (37)
No (37)
6His, C-terminus (6)
6His, N-terminus (3)
8His, N-terminus (1)
DDK (Flag) (4)
Fc, C-terminus (2)
GST (1)
His (9)
His,C-terminus (1)
His,N-terminus (1)
His-T7 (2)
Myc-DDK (Flag) (3)
Dog (1)
Human (20)
Mouse (10)
Pig (1)
Rat (4)
293T Cells (1)
Baculovirus (1)
E. coli (14)
HEK 293 Cells (13)
Human Cells (4)
Mammalian Cells (3)
Wheat Germ Extract (1)
Purified (16)
Low endotoxin level (20)
Biologically active (2)
Select
E. coli
None
Biologically active
41.0 kDa
2 µg/$257; 10 µg/$341; 100 µg/$947; 250 µg/$1,475; 1 mg/$2,622; 500 µg/$1,918
LCN2 / Lipocalin 2 / NGAL Protein - Recombinant Neutrophil Gelatinase Associated Lipocalin By SDS-PAGE
Select
E. coli
His
21.7 kDa
10 µg/$297; 50 µg/$574; 100 µg/$917; 200 µg/$1,085; 1 mg/$2,410
Select
HEK 293 Cells
DDK (Flag)
Less than 0.1 EU/µg protein (determined by LAL method).
~25.0 kDa
50 µg/$1,014; 10 µg/$417
Select
HEK 293 Cells
8His, N-terminus
22 kDa
100 µg/$288
LCN2 / Lipocalin 2 / NGAL Protein - 12.5% SDS-PAGE of human LCN2 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
47.41 kDa
10 µg/$461; 25 µg/$611
Select
HEK 293 Cells
6His, N-terminus
22 kDa
200 µl/$273
LCN2 / Lipocalin 2 / NGAL Protein - Recombinant  Neutrophil Gelatinase Associated Lipocalin By SDS-PAGE
Select
E. coli
His-T7
23.9 kDa
10 µg/$278; 50 µg/$460; 100 µg/$734; 200 µg/$917; 1 mg/$2,013
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
22 kDa
50 µg/$473; 100 µg/$677
LCN2 / Lipocalin 2 / NGAL Protein - Purified recombinant protein LCN2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
22.4 kDa
20 µg/$922
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
22.3 kDa
50 µg/$473; 100 µg/$677
LCN2 / Lipocalin 2 / NGAL Protein
Select
E. coli
His
100 µg/$351; 500 µg/$694
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.9kD
10 µg/$253; 50 µg/$327; 500 µg/$1,178; 1 mg/$1,682
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48kD
10 µg/$253; 50 µg/$327; 500 µg/$1,178; 1 mg/$1,682
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.6kD
10 µg/$267; 50 µg/$376; 500 µg/$1,439; 1 mg/$2,055
Select
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.8kD
10 µg/$267; 50 µg/$376; 500 µg/$1,439; 1 mg/$2,055
Select
E. coli
None
Less than 0.1 ng/µg of protein.
20 kDa
50 µg/$565; 1 mg/$5,359; 10 µg/$358
LCN2 / Lipocalin 2 / NGAL Protein - Binding activity of mNGAL
Select
HEK 293 Cells
None
Less than 0.01 ng/µg (determined by LAL method).
The 195 amino acid recombinant protein has a predicted molecular mass of approximately 23 kD. The DTT-reduced and non-reduced protein migrate at approximately 26-29 and 25-28 kD by SDS-PAGE respectively. The N-terminal amino acid is blocked.
10 µg/$282; 25 µg/$340; 100 µg/$587; 500 µg/$1,618
LCN2 / Lipocalin 2 / NGAL Protein - Binding activity of hNGAL
Select
HEK 293 Cells
None
Less than 0.01 ng/µg (determined by LAL method).
The 193 amino acid recombinant protein has a predicted molecular mass of approximately 22 kD. The DTT-reduced and non-reduced protein migrate at approximately 24-28 and 23-26 kD by SDS-PAGE respectively. The N-terminal amino acid is blocked.
10 µg/$282; 25 µg/$340; 100 µg/$587; 500 µg/$1,618
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.9 kDa
10 µg/$344; 50 µg/$419
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48 kDa
10 µg/$344; 50 µg/$419
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.6 kDa
10 µg/$358; 50 µg/$469
Select
E. coli
177 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
19.58 kDa
10 mg/$4,268; 5 mg/$3,202; 1 mg/$1,868; 0.5 mg/$1,362; 200 µg/$1,023; 100 µg/$710; 50 µg/$521
LCN2 / Lipocalin 2 / NGAL Protein
Select
HEK 293 Cells
His
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
22 kDa. DTT-reduced protein migrates as 23-25 kDa
50 µg/$853; 10 µg/$385
LCN2 / Lipocalin 2 / NGAL Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
E. coli
6His, N-terminus
22.6 kDa
10 µg/$255; 50 µg/$305
LCN2 / Lipocalin 2 / NGAL Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
22.4 kDa
100 µg/$435
Viewing 1-25 of 37 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).