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Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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LAMTOR4
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.
| Gene Name: | late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 |
| Synonyms: | LAMTOR4, C7orf59 |
| Target Sequences: | NP_001074577.1 Q8CF66 |
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