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LAMTOR3 / MP1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
| Gene Name: | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 |
| Synonyms: | LAMTOR3, MAPBP, MAPK scaffold protein 1, MAPKSP1, MAP2K1IP1, MEK binding partner 1, MEK-binding partner 1, MP1, Ragulator3, PRO0633 |
| Target Sequences: | NM_021970 NP_068805.1 Q9UHA4 |
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