LAMTOR1

late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.

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Products

Antibodies (11)

Proteins (3)

ELISA Kits (1)

Type

Over-Expression Lysate (2)

Primary (11)

Recombinant (1)

Sandwich (1)

Target

LAMTOR1 (15)

Reactivity

Human (12)

Mouse (5)

Rat (2)

Application

IHC (3)

IHC-P (2)

WB (7)

ELISA (5)

ICC (1)

IF (4)

Peptide-ELISA (1)

Host

rabbit (11)

Isotype

IgG (9)

Clonality

polyclonal pc (11)

Format

96-Well Strip Plate (1)

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (8)

Epitope

aa111-161 (1)

aa50-250 (1)

Publications

No (15)

Sample Type

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

6His, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Purification

Purified (1)

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LAMTOR1 Antibody LS-C201197

Antibody:

LAMTOR1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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LAMTOR1 Antibody (aa50-250) LS-C143599

Antibody:

LAMTOR1 Rabbit anti-Human Polyclonal (aa50-250) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 ml/$386

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LAMTOR1 Antibody LS-C682300

Antibody:

LAMTOR1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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LAMTOR1 Antibody (HRP) LS-C680752

Antibody:

LAMTOR1 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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LAMTOR1 Antibody (Biotin) LS-C680749

Antibody:

LAMTOR1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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LAMTOR1 Antibody (FITC) LS-C680751

Antibody:

LAMTOR1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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LAMTOR1 Antibody LS-C803639

Antibody:

LAMTOR1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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LAMTOR1 Antibody LS-C767838

Antibody:

LAMTOR1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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LAMTOR1 Antibody LS-C668424

Antibody:

LAMTOR1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

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LAMTOR1 Antibody LS-C747037

Antibody:

LAMTOR1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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LAMTOR1 Antibody (aa111-161) LS-C762802

Antibody:

LAMTOR1 Rabbit anti-Human Polyclonal (aa111-161) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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Human LAMTOR1 Protein (Recombinant 6His, N-terminus) (aa1-161) - LS-G56795

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human LAMTOR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84692

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.6 kDa

Price:

20 µg/$150

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Human LAMTOR1 (Sandwich ELISA) ELISA Kit - LS-F33813

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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LAMTOR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112128

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.6 kDa

Price:

100 µg/$494

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