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LAMC2 / Laminin Gamma 2

laminin, gamma 2

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature.

Gene Name: laminin, gamma 2
Family/Subfamily: Laminin , not assigned-Laminin
Synonyms: LAMC2, B2T, BM600, EBR2, CSF 140 kDa subunit, EBR2A, Epiligrin subunit gamma, LAMNB2, LAMB2T, Laminin B2t chain, Laminin gamma-2 chain, Nicein subunit gamma, Kalinin-105kDa, Ladsin 140 kDa subunit, BM600-100kDa, Kalinin subunit gamma, Laminin subunit gamma-2, Laminin, gamma 2, Laminin-5 subunit gamma, Nicein-100kDa
Target Sequences: NM_005562 NP_005553.2 Q13753

☰ Filters
Antibodies (68)
Proteins (14)
ELISA Kits (4)
Custom (2)
Over-Expression Lysate (6)
Primary (68)
Recombinant (8)
Sandwich (2)
LAMC2 / Laminin Gamma 2 (86)
Human (49)
Mouse (19)
Rat (12)
IHC (11)
IHC-P (4)
WB (65)
ELISA (17)
ICC (1)
IF (1)
IP (1)
rabbit (62)
mouse (6)
Product Group
IHCPlus (1)
IgG (16)
IgG1 (6)
monoclonal mc (6)
polyclonal pc (62)
96-Well Strip Plate (4)
AP Conjugated (2)
APC (5)
APC Conjugated (7)
Azide-free (1)
Biotin Conjugated (9)
Cy3 Conjugated (5)
Cy7 Conjugated (5)
FITC Conjugated (9)
HRP Conjugated (8)
PE Conjugated (7)
Unconjugated (16)
aa416-602 (10)
aa1003-1192 (8)
aa187-415 (8)
aa28-196 (8)
aa941-970 (8)
aa972-1191 (8)
C-Terminus (1)
C-terminal (1)
aa1160-1180 (1)
aa445-657 (1)
No (86)
Plasma (2)
Serum (2)
Tissue Homogenates (2)
GST, N-terminus (1)
His, N-Terminal (1)
His-GST (3)
His-T7 (1)
Myc-DDK (Flag) (8)
Human (9)
Mouse (1)
Rat (1)
293T Cells (3)
E. coli (5)
HEK 293 Cells (5)
Wheat Germ Extract (1)
LAMC2 / Laminin Gamma 2 Antibody - LAMC2 / Laminin Gamma 2 antibody. IHC(P): Human Lung Cancer Tissue.
Select
LAMC2 / Laminin Gamma 2 Rabbit anti-Human Polyclonal (aa1160-1180) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$421
LAMC2 / Laminin Gamma 2 Antibody - IHC of paraffin-embedded BT483 xenograft using Laminin gamma 2 antibody at 1:250 dilution.
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LAMC2 / Laminin Gamma 2 Rabbit anti-Human Polyclonal (aa445-657) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$398
LAMC2 / Laminin Gamma 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$744
LAMC2 / Laminin Gamma 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$821
LAMC2 / Laminin Gamma 2 Protein - Recombinant Laminin Gamma 2 By SDS-PAGE
Select
E. coli
His, N-Terminal
22.3 kDa
10 µg/$257; 50 µg/$341; 100 µg/$536; 200 µg/$670; 1 mg/$1,582; 500 µg/$1,195; 5 mg/$3,322
LAMC2 / Laminin Gamma 2 Antibody - Western blot analysis of extracts of rat lung cells.
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LAMC2 / Laminin Gamma 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
LAMC2 / Laminin Gamma 2 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
LAMC2 / Laminin Gamma 2 Rabbit anti-Human Polyclonal (aa416-602) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
LAMC2 / Laminin Gamma 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
130.99 kDa
20 µg/$200
LAMC2 / Laminin Gamma 2 Antibody - Western blot of recombinant LAMC2 / Laminin Gamma 2.
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LAMC2 / Laminin Gamma 2 Rabbit anti-Human Polyclonal (aa416-602) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$307; 200 µl/$355; 500 µl/$509; 1 ml/$594
LAMC2 / Laminin Gamma 2 Antibody - Immunohistochemistry of Laminin gamma-2 antibody
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LAMC2 / Laminin Gamma 2 Rabbit anti-Human Polyclonal (C-terminal) Antibody
Rat, Human
ELISA, IHC, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
LAMC2 / Laminin Gamma 2 Antibody - Western blot analysis of LAMC2 using HepG2 whole cells lysates
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LAMC2 / Laminin Gamma 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µl/$369; 200 µl/$411
LAMC2 / Laminin Gamma 2 Antibody - Western blot of recombinant LAMC2 / Laminin Gamma 2.
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LAMC2 / Laminin Gamma 2 Rabbit anti-Human Polyclonal (aa28-196) Antibody
Human
ICC, IP, WB
Unconjugated
100 µl/$299; 200 µl/$341; 500 µl/$481; 1 ml/$551
Select
LAMC2 / Laminin Gamma 2 Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
100 µl/$870
Select
LAMC2 / Laminin Gamma 2 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
100 µl/$870
Select
LAMC2 / Laminin Gamma 2 Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
100 µl/$870
Select
LAMC2 / Laminin Gamma 2 Mouse anti-Human Monoclonal (AP) Antibody
Human
ELISA, IHC, WB
AP Conjugated
100 µl/$870
Select
LAMC2 / Laminin Gamma 2 Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
100 µl/$870
Select
LAMC2 / Laminin Gamma 2 Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
100 µl/$870
Select
LAMC2 / Laminin Gamma 2 Rabbit anti-Human Polyclonal (aa941-970) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$642
Select
LAMC2 / Laminin Gamma 2 Rabbit anti-Mouse Polyclonal (aa941-970) (APC) Antibody
Mouse
ELISA, WB
APC Conjugated
200 µl/$825
Select
LAMC2 / Laminin Gamma 2 Rabbit anti-Mouse Polyclonal (aa941-970) (AP) Antibody
Mouse
ELISA, WB
AP Conjugated
200 µl/$825
LAMC2 / Laminin Gamma 2 Antibody - Immunohistochemistry image at a dilution of 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Select
LAMC2 / Laminin Gamma 2 Rabbit anti-Human Polyclonal Antibody
Human
IHC-P, WB
Unconjugated
50 µg/$284; 100 µg/$348
Select
LAMC2 / Laminin Gamma 2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$284; 100 µg/$348
Select
LAMC2 / Laminin Gamma 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$331
LAMC2 / Laminin Gamma 2 Antibody - Western blot analysis of lysate from K562 cells, using LAMC2 Antibody.
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LAMC2 / Laminin Gamma 2 Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, WB
Unconjugated
50 µg/$318; 100 µg/$378
Viewing 1-25 of 86 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).